Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0Q5SL
|
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| Former ID |
DNC001654
|
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| Drug Name |
BRL54443
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C14H18N2O
|
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| InChI |
InChI=1S/C14H18N2O/c1-16-6-4-10(5-7-16)13-9-15-14-3-2-11(17)8-12(13)14/h2-3,8-10,15,17H,4-7H2,1H3
|
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| InChIKey |
WKNFADCGOAHBPG-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
5580999, 8151627, 11110825, 11113936, 15220671, 26752089, 29221602, 47365411, 47440474, 48185186, 50104743, 77824568, 85208985, 90341506, 104300587, 124749544, 124879371, 124879372, 124879373, 125093101, 125568956, 129594833, 135698379, 136368024, 137005651, 144115754, 152344534, 162009742, 162023008, 162220574, 162957191, 164045135, 172648765, 178100756, 198966450, 210274835, 210280467, 216088069, 223380665, 223674589, 223702804, 223872422, 225362715, 229554251, 241182155, 242060374, 242181581, 249768037, 249860760, 250225738
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| Target and Pathway | |||||
| Target(s) | 5-hydroxytryptamine 1E receptor | Target Info | Agonist | [2] | |
| KEGG Pathway | cAMP signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Serotonergic synapse | |||||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| 5HT1 type receptor mediated signaling pathway | |||||
| Reactome | Serotonin receptors | ||||
| G alpha (i) signalling events | |||||
| WikiPathways | Serotonin HTR1 Group and FOS Pathway | ||||
| Monoamine GPCRs | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3927). | ||||
| REF 2 | Characterization of the serotonin receptor mediating contraction in the mouse thoracic aorta and signal pathway coupling. J Pharmacol Exp Ther. 2001 Apr;297(1):88-95. | ||||
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