Drug Information

Drug General Information
Drug ID
D0Q5QC
Former ID
DNC010606
Drug Name
EMD-534085
Drug Type
Small molecular drug
Indication Hematological malignancies [ICD9: 200-209; ICD10:C81-C86] Phase 1 [548638]
Structure
Download
2D MOL

3D MOL
Formula
C25H31F3N4O2
Canonical SMILES
CN(C)CCNC(=O)NCC1CCC2C(NC3=C(C2O1)C=C(C=C3)C(F)(F)F)C4=<br />CC=CC=C4
InChI
1S/C25H31F3N4O2/c1-32(2)13-12-29-24(33)30-15-18-9-10-19-22(16-6-4-3-5-7-16)31-21-11-8-17(25(26,27)28)14-20(21)23(19)34-18/h3-8,11,14,18-19,22-23,31H,9-10,12-13,15H2,1-2H3,(H2,29,30,33)/t18-,19+,22+,23+/m1/s1
InChIKey
MARIUIDCPUZLKZ-FUKQBSRTSA-N
PubChem Compound ID
23634407
Target and Pathway
Target(s) mRNA of kinesin spindle protein Target Info Inhibitor [530716]
Reactome MHC class II antigen presentation
Kinesins
WikiPathways MHC class II antigen presentation
Kinesins
References
Ref 548638Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027260)
Ref 530716Bioorg Med Chem Lett. 2010 Mar 1;20(5):1491-5. Epub 2010 Jan 25.The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5.

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