Drug General Information
Drug ID
D0Q4SD
Former ID
DAP000085
Drug Name
Eplerenone
Synonyms
Epoxymexrenone; Inspra; Selara; CGP-30083; Inspra (TN); SC-66110; Eplerenone (JAN/USAN/INN); Inspra, Epoxymexrenone, CGP30083, SC-66110,Eplerenone; 7alpha-methoxycarbonyl-3-oxo-9,11alpha-epoxy-17alpha-pregn-4-ene-21,17-carbolactone
Drug Type
Small molecular drug
Indication Heart failure [ICD9: 428; ICD10:I50] Approved [536361], [539902]
Therapeutic Class
Antihypertensive Agents
Company
Pfizer Pharmaceuticals
Structure
Download
2D MOL

3D MOL

Formula
C24H30O6
InChI
InChI=1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1
InChIKey
JUKPWJGBANNWMW-VWBFHTRKSA-N
CAS Number
CAS 107724-20-9
PubChem Compound ID
PubChem Substance ID
ChEBI ID
ChEBI:31547
SuperDrug ATC ID
C03DA04
SuperDrug CAS ID
cas=107724209
Target and Pathway
Target(s) Mineralocorticoid receptor Target Info Modulator [556264]
KEGG Pathway Aldosterone-regulated sodium reabsorption
PathWhiz Pathway Kidney Function
WikiPathways ACE Inhibitor Pathway
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 539902(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2876).
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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