Drug Information

Drug General Information
Drug ID
D0Q3YO
Former ID
DAP000325
Drug Name
Cinnarizine
Synonyms
Aplactan; Aplexal; Apotomin; Artate; Carecin; Cerebolan; Cinaperazine; Cinarizina; Cinarizine; Cinazyn; Cinnacet; Cinnageron; Cinnarizinum; Corathiem; Denapol; Dimitron; Dimitronal; Eglen; Folcodal; Giganten; Glanil; Hilactan; Ixertol; Katoseran; Labyrin; Lazeta; Libotasin; Marisan; Midronal; Mitronal; Olamin; Processine; Sedatromin; Senoger; Sepan; Siptazin; Spaderizine; Stugeron; Stutgeron; Stutgin; Toliman; Votegol; Zepamol; Cinnarizine Stugeron; C 5270; MD 516; R 1575; R 516; Cero-Aterin; Cinarizina [INN-Spanish]; Cinnarizinum [INN-Latin]; R-516; Stugeron (TN); Stunarone (TN); Cinnarizine (JAN/USAN/INN); Cinnarizine [USAN:INN:BAN:JAN]; N-Benzhydryl-N'-cinnamylpiperazine; 1-(Diphenylmethyl)-4-(3-phenyl-2-propenyl)piperazine; 1-(diphenylmethyl)-4-(3-phenyl-2-propenyl)-piperazine; 1-(diphenylmethyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine; 1-Benzhydryl-4-cinnamylpiperazin; 1-Cinnamyl-4-(diphenylmethyl)piperazine; 1-benzhydryl-4-[(E)-3-phenylprop-2-enyl]piperazine; 1-trans-Cinnamyl-4-diphenylmethylpiperazine
Drug Type
Small molecular drug
Indication Vertigo meniere's disease [ICD9: 386.0, 438.85, 780.4; ICD10:H81, H81.0, R42] Approved [550678]
Therapeutic Class
Antiallergic Agents
Company
Janssen Pharmaceutica
Structure
Download
2D MOL

3D MOL
Formula
C26H28N2
Canonical SMILES
C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=CC=C4
InChI
1S/C26H28N2/c1-4-11-23(12-5-1)13-10-18-27-19-21-28(22-20-27)26(24-14-6-2-7-15-24)25-16-8-3-9-17-25/h1-17,26H,18-22H2/b13-10+
InChIKey
DERZBLKQOCDDDZ-JLHYYAGUSA-N
CAS Number
CAS 298-57-7
PubChem Compound ID
1547484
PubChem Substance ID
145189, 597357, 855570, 7848358, 7978948, 8652487, 10321216, 10517604, 10852043, 14803894, 17404877, 24278320, 32247729, 47216936, 47440424, 47515486, 47810927, 47810928, 48110619, 48415781, 49698416, 50012381, 50103929, 50103930, 50103931, 50140413, 53777420, 56422441, 56464175, 57288760, 57409047, 81093277, 85148348, 85173395, 85209898, 85231348, 85788038, 89099692, 89850280, 90340734, 92125122, 92303637, 103224720, 103913696, 103928925, 106681504, 110522301, 117706973, 121361114, 121362793
ChEBI ID
ChEBI:31403
SuperDrug ATC ID
N07CA02
SuperDrug CAS ID
cas=000298577
Target and Pathway
Target(s) Histamine H1 receptor Target Info Antagonist [534845], [535477]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Histamine H1 receptor mediated signaling pathway
Reactome Histamine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
IL-4 Signaling Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 550678Drug information of Cinnarizine, 2008. eduDrugs.
Ref 534845Effects of calcium-antagonistic drugs on the stimulation by carbamoylcholine and histamine of phosphatidylinositol turnover in longitudinal smooth muscle of guinea-pig ileum. Biochem J. 1976 Nov 15;160(2):163-9.
Ref 535477Central effects of cinnarizine: restricted use in aircrew. Aviat Space Environ Med. 2002 Jun;73(6):570-4.

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