Drug General Information
Drug ID	D0Q3CX
Former ID	DNC008621
Drug Name	6-(4-Methylpyridin-3-yl)-2-naphthonitrile
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529624]
Structure		Download 2D MOL 3D MOL
Formula	C17H12N2
Canonical SMILES	CC1=C(C=NC=C1)C2=CC3=C(C=C2)C=C(C=C3)C#N
InChI	1S/C17H12N2/c1-12-6-7-19-11-17(12)16-5-4-14-8-13(10-18)2-3-15(14)9-16/h2-9,11H,1H3
InChIKey	BVEDDOVOLJETRX-UHFFFAOYSA-N
PubChem Compound ID	25034343
Target and Pathway
Target(s)	Cytochrome P450 11B1, mitochondrial	Target Info	Inhibitor	[529624]
BioCyc Pathway	Superpathway of steroid hormone biosynthesis
	Glucocorticoid biosynthesis
	Mineralocorticoid biosynthesis
KEGG Pathway	Steroid hormone biosynthesis
	Metabolic pathways
PathWhiz Pathway	Steroidogenesis
Reactome	Glucocorticoid biosynthesis
	Endogenous sterols
WikiPathways	Metapathway biotransformation
	Oxidation by Cytochrome P450
	Metabolism of steroid hormones and vitamin D
	Corticotropin-releasing hormone
References
Ref 529624	J Med Chem. 2008 Aug 28;51(16):5064-74. Epub 2008 Aug 1.Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization onpotency and selectivity.
Ref 529624	J Med Chem. 2008 Aug 28;51(16):5064-74. Epub 2008 Aug 1.Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization onpotency and selectivity.

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