Drug General Information
Drug ID	D0Q0JI
Former ID	DIB002573
Drug Name	ASP-4058
Indication	Multiple scierosis [ICD9: 340; ICD10:G35]		Phase 1	[533005]
Company	Astellas Pharma Inc
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Sphingosine 1-phosphate receptor 1	Target Info	Modulator	[533005]
	Sphingosine 1-phosphate receptor 5	Target Info	Modulator	[533005]
KEGG Pathway	FoxO signaling pathway
	Sphingolipid signaling pathway
	Neuroactive ligand-receptor interactionhsa04071:Sphingolipid signaling pathway
	Neuroactive ligand-receptor interaction
NetPath Pathway	IL4 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	IL2 Signaling Pathway
Pathway Interaction Database	Fc-epsilon receptor I signaling in mast cells
	S1P3 pathway
	S1P1 pathway
	Sphingosine 1-phosphate (S1P) pathway
	PDGFR-beta signaling pathways1p_s1p4_pathway:S1P4 pathway
	S1P5 pathway
Reactome	G alpha (i) signalling events
	Lysosphingolipid and LPA receptorsR-HSA-418594:G alpha (i) signalling events
	Lysosphingolipid and LPA receptors
WikiPathways	Signal Transduction of S1P Receptor
	Small Ligand GPCRs
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, OtherWP26:Signal Transduction of S1P Receptor
References
Ref 533005	ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile. PLoS One. 2014 Oct 27;9(10):e110819.
Ref 533005	ASP4058, a novel agonist for sphingosine 1-phosphate receptors 1 and 5, ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile. PLoS One. 2014 Oct 27;9(10):e110819.

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