Drug Information
Drug General Information | |||||
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Drug ID |
D0PN6Z
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Former ID |
DIB020187
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Drug Name |
L-AP4
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Synonyms |
L-2-amino-4-phosphonobutiric acid; L-AP4; S-2-amino-4-phosphonobutyrate
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [538887] | ||
Structure |
Download2D MOL |
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Formula |
C4H10NO5P
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InChI |
InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
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InChIKey |
DDOQBQRIEWHWBT-VKHMYHEASA-N
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PubChem Compound ID | |||||
PubChem Substance ID |
3153190, 4252812, 7978716, 10259084, 11113375, 11457587, 11459535, 14818549, 24891296, 26651777, 26758214, 33502534, 49896033, 50104307, 57395670, 78666740, 81093357, 90458771, 103205265, 103920819, 104429542, 117682323, 124635408, 124877291, 124877292, 127719431, 132522189, 134345882, 135158089, 135650507, 135651136, 140341569, 162093643, 163688614, 228129920, 241181546
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Target and Pathway | |||||
Target(s) | Metabotropic glutamate receptor 4 | Target Info | Agonist | [525456] | |
mGlu6 receptor | Target Info | Agonist | [534382] | ||
Metabotropic glutamate receptor 8 | Target Info | Agonist | [525476] | ||
Metabotropic glutamate receptor 7 | Target Info | Agonist | [525945] | ||
PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
Metabotropic glutamate receptor group III pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
Metabotropic glutamate receptor group III pathway | |||||
References | |||||
Ref 525456 | Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor. J Biol Chem. 1999 Apr 9;274(15):10008-13. | ||||
Ref 525476 | Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8. Brain Res Mol Brain Res. 1999 Apr 20;67(2):201-10. | ||||
Ref 525945 | Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2000 Dec;362(6):546-54. | ||||
Ref 534382 | Cloning, distribution and functional expression of the human mGlu6 metabotropic glutamate receptor. Neuropharmacology. 1997 Feb;36(2):145-52. |
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