Drug General Information
Drug ID
D0PI1C
Former ID
DIB020014
Drug Name
HQL-79
Synonyms
HQL79; HQL 79
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541768]
Structure
Download
2D MOL
Formula
C22H27N5O
InChI
InChI=1S/C22H27N5O/c1-3-8-18(9-4-1)22(19-10-5-2-6-11-19)28-20-13-16-27(17-14-20)15-7-12-21-23-25-26-24-21/h1-6,8-11,20,22H,7,12-17H2,(H,23,24,25,26)
InChIKey
TZQGXAHOROZEKN-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Glutathione S-transferase Target Info Inhibitor [528089]
BioCyc Pathway C20 prostanoid biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
WikiPathways Arachidonic acid metabolism
Aryl Hydrocarbon Receptor
Integrated Pancreatic Cancer Pathway
References
Ref 541768(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6662).
Ref 528089Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J Biol Chem. 2006 Jun 2;281(22):15277-86. Epub 2006 Mar 17.

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