Drug Information
Drug General Information | |||||
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Drug ID |
D0PF3J
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Former ID |
DNC006861
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Drug Name |
DOLASTATIN-10
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Drug Type |
Small molecular drug
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Indication | Cancer [ICD9: 140-229; ICD10:C00-C96] | Phase 2 | [521453] | ||
Structure |
Download2D MOL |
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Formula |
C42H68N6O6S
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Canonical SMILES |
CCC(C)C(C(CC(=O)N1CCCC1C(C(C)C(=O)NC(CC2=CC=CC=C2)C3=NC<br />=CS3)OC)OC)N(C)C(=O)C(C(C)C)NC(=O)C(C(C)C)N(C)C
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InChI |
1S/C42H68N6O6S/c1-13-28(6)37(47(10)42(52)35(26(2)3)45-40(51)36(27(4)5)46(8)9)33(53-11)25-34(49)48-22-17-20-32(48)38(54-12)29(7)39(50)44-31(41-43-21-23-55-41)24-30-18-15-14-16-19-30/h14-16,18-19,21,23,26-29,31-33,35-38H,13,17,20,22,24-25H2,1-12H3,(H,44,50)(H,45,51)/t28-,29+,31-,32-,33+,35-,36-,37-,38+/m1/s1
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InChIKey |
OFDNQWIFNXBECV-MOFABKIVSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Tubulin | Target Info | Inhibitor | [534612] | |
Tubulin beta | Target Info | Inhibitor | [528306] | ||
Tubulin beta-2 chain | Target Info | Inhibitor | [528306] | ||
PANTHER Pathway | Cytoskeletal regulation by Rho GTPase | ||||
Huntington disease | |||||
References | |||||
Ref 528306 | Bioorg Med Chem Lett. 2006 Sep 15;16(18):4804-7. Epub 2006 Jul 11.Total synthesis and biological evaluation of ustiloxin natural products and two analogs. | ||||
Ref 534612 | J Med Chem. 1998 Apr 23;41(9):1524-30.Synthesis and biological activity of chimeric structures derived from the cytotoxic natural compounds dolastatin 10 and dolastatin 15. |
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