Drug Information

Drug General Information
Drug ID
D0PE1A
Former ID
DNC000519
Drug Name
DBO-11
Drug Type
Small molecular drug
Indication Cancer pain [ICD9: 140-229, 338,780; ICD10:R52, G89] Terminated [546673]
Therapeutic Class
Analgesics
Structure
Download
2D MOL

3D MOL
Formula
C18H24N4O3
Canonical SMILES
CCCN1C2=C(C(=O)N(C1=O)CCC)NC(=N2)C3CC4CC3C5C4O5
InChI
1S/C18H24N4O3/c1-3-5-21-16-12(17(23)22(6-4-2)18(21)24)19-15(20-16)11-8-9-7-10(11)14-13(9)25-14/h9-11,13-14H,3-8H2,1-2H3,(H,19,20)/t9-,10-,11-,13+,14-/m0/s1
InChIKey
OQCJPFYWFGUHIN-JZKMBYMZSA-N
CAS Number
CAS 166374-49-8
PubChem Compound ID
23724971
PubChem Substance ID
47206850, 57388143, 134339927, 137263821
Target and Pathway
Target(s) Mu-type opioid receptor Target Info Agonist [536058]
KEGG Pathway Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addiction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Opioid Signalling
GPCR ligand binding
GPCR downstream signaling
References
Ref 546673Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009577)
Ref 536058Emerging analgesics in cancer pain management. Expert Opin Emerg Drugs. 2005 Feb;10(1):151-71.

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