Drug General Information
Drug ID	D0P9FT
Former ID	DIB011542
Drug Name	REC-15-2739
Synonyms	SB-216469; REC-15-2869; REC-15-3011; REC-22/009
Drug Type	Small molecular drug
Indication	Prostate disease [ICD10:N42.9]		Discontinued in Phase 2	[545508]
Company	Recordati SpA
Structure		Download 2D MOL 3D MOL
Formula	C31H33N3O4
Canonical SMILES	c12oc(c(c(=O)c1cccc2C(=O)NCCCN1CCN(c2c(OC)cccc2)CC1)C)c<br />1ccccc1
CAS Number	CAS 152735-23-4
PubChem Compound ID	148842
Target and Pathway
Target(s)	Alpha-1D adrenergic receptor	Target Info	Modulator	[534138]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Salivary secretion
NetPath Pathway	IL2 Signaling Pathway
Reactome	Adrenoceptors
	G alpha (q) signalling events
	G alpha (12/13) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 545508	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003537)
Ref 534138	Functional antagonistic activity of Rec 15/2739, a novel alpha-1 antagonist selective for the lower urinary tract, on noradrenaline-induced contraction of human prostate and mesenteric artery. J Pharmacol Exp Ther. 1996 Jun;277(3):1237-46.

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