Drug Information

Drug General Information
Drug ID
D0P4VX
Former ID
DAP000058
Drug Name
Terlipressin
Synonyms
Glypressin; Lucassin; Terlipressina; Terlipressine; Terlipressinum; Glypressin (TN); HS-2028; Terlipressin [BAN:INN]; Terlipressina [INN-Spanish]; Terlipressine [INN-French]; Terlipressinum [INN-Latin]; N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Approved [536973]
Therapeutic Class
Vasoconstrictor Agents
Company
Ferring Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C52H74N16O15S2
Canonical SMILES
C1CC(N(C1)C(=O)C2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(<br />C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)N<br />C(=O)CNC(=O)CNC(=O)CN)C(=O)NC(CCCCN)C(=O)NCC(=O)N
InChI
1S/C52H74N16O15S2/c53-17-5-4-9-31(45(76)60-23-41(57)72)63-51(82)38-10-6-18-68(38)52(83)37-27-85-84-26-36(61-44(75)25-59-43(74)24-58-42(73)22-54)50(81)65-34(20-29-11-13-30(69)14-12-29)48(79)64-33(19-28-7-2-1-3-8-28)47(78)62-32(15-16-39(55)70)46(77)66-35(21-40(56)71)49(80)67-37/h1-3,7-8,11-14,31-38,69H,4-6,9-10,15-27,53-54H2,(H2,55,70)(H2,56,71)(H2,57,72)(H,58,73)(H,59,74)(H,60,76)(H,61,75)(H,62,78)(H,63,82)(H,64,79)(H,65,81)(H,66,77)(H,67,80)/t31-,32-,33-,34-,35-,36-,37-,38-/m0/s1
InChIKey
BENFXAYNYRLAIU-QSVFAHTRSA-N
CAS Number
CAS 14636-12-5
PubChem Compound ID
72081
PubChem Substance ID
8195004, 14792660, 43128306, 46504626, 47208323, 50062330, 50887237, 57318514, 92098554, 93815097, 104352042, 117569638, 124896640, 126667357, 134337386, 135030842, 135752714, 137006272, 144206925, 152134056, 160965815, 162174262, 163319696, 164814212, 180372198, 184545337, 187072154, 223659635, 226411668, 252218927, 252359163
SuperDrug ATC ID
H01BA04
SuperDrug CAS ID
cas=014636125
Target and Pathway
Target(s) Vasopressin V1a receptor Target Info Stimulator [537593]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Reactome Vasopressin-like receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 536973Pharmacology, clinical efficacy and safety of terlipressin in esophageal varices bleeding, septic shock and hepatorenal syndrome. Expert Rev Gastroenterol Hepatol. 2007 Dec;1(2):207-17.
Ref 537593Investigational vasopressin receptor modulators in the pipeline. Expert Opin Investig Drugs. 2009 Aug;18(8):1119-31.

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