Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0P1FJ
|
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| Former ID |
DNC000245
|
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| Drug Name |
Aprophen
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1], [2] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C21H27NO2
|
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| Canonical SMILES |
CCN(CC)CCOC(=O)C(C)(C1=CC=CC=C1)C2=CC=CC=C2
|
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| InChI |
1S/C21H27NO2/c1-4-22(5-2)16-17-24-20(23)21(3,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15H,4-5,16-17H2,1-3H3
|
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| InChIKey |
DIDYGLSKVUKRRP-UHFFFAOYSA-N
|
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| CAS Number |
CAS 3563-01-7
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
6310258, 8194443, 14951174, 29216370, 43127515, 50025618, 57318020, 57825662, 79687531, 81093318, 85209440, 88826488, 103193266, 103919137, 104349726, 108205614, 126424253, 127738368, 134222727, 134339721, 135026637, 144205532, 164235787, 165805006, 170466081, 179294171, 198989935, 228472588, 249950688
|
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| Target and Pathway | |||||
| Target(s) | Muscarinic acetylcholine receptor M5 | Target Info | Antagonist | [1], [2] | |
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| Cholinergic synapse | |||||
| Regulation of actin cytoskeleton | |||||
| PANTHER Pathway | Alzheimer disease-amyloid secretase pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Reactome | Muscarinic acetylcholine receptors | ||||
| G alpha (q) signalling events | |||||
| WikiPathways | Monoamine GPCRs | ||||
| Calcium Regulation in the Cardiac Cell | |||||
| Regulation of Actin Cytoskeleton | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | M1 muscarinic antagonists interact with sigma recognition sites. Life Sci. 1991;49(17):1229-35. | ||||
| REF 2 | The muscarinic antagonists aprophen and benactyzine are noncompetitive inhibitors of the nicotinic acetylcholine receptor. Mol Pharmacol. 1987 Nov;32(5):678-85. | ||||
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