Drug General Information
Drug ID	D0OW6Z
Former ID	DIB006861
Drug Name	Sipoglitazar
Synonyms	TAK-654
Indication	Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1]		Terminated	[532486]
Company	Takeda Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1(c(nn(c1)Cc1ccc(OCc2nc(sc2)c2ccccc2)cc1)OCC)CCC(=O)O
CAS Number	CAS 342026-92-0
Target and Pathway
Target(s)	Peroxisome proliferator activated receptor gamma	Target Info	Modulator	[532486]
	Peroxisome proliferator activated receptor alpha	Target Info	Modulator	[532486]
KEGG Pathway	PPAR signaling pathway
	AMPK signaling pathway
	Osteoclast differentiation
	Huntington's disease
	Pathways in cancer
	Transcriptional misregulation in cancer
	Thyroid cancerhsa03320:PPAR signaling pathway
	cAMP signaling pathway
	Adipocytokine signaling pathway
	Glucagon signaling pathway
	Non-alcoholic fatty liver disease (NAFLD)
	Hepatitis C
NetPath Pathway	IL1 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	Leptin Signaling Pathway
PANTHER Pathway	CCKR signaling map ST
Pathway Interaction Database	Noncanonical Wnt signaling pathway
	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
	Signaling events mediated by HDAC Class I
	RXR and RAR heterodimerization with other nuclear receptor
	Regulation of retinoblastoma proteinrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptor
Reactome	PPARA activates gene expression
	Transcriptional regulation of white adipocyte differentiation
	Nuclear Receptor transcription pathwayR-HSA-1368082:RORA activates gene expression
	BMAL1:CLOCK,NPAS2 activates circadian gene expression
	YAP1- and WWTR1 (TAZ)-stimulated gene expression
	Transcriptional activation of mitochondrial biogenesis
	Activation of gene expression by SREBF (SREBP)
	Nuclear Receptor transcription pathway
	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
	Circadian Clock
WikiPathways	Wnt Signaling Pathway Netpath
	Nuclear Receptors in Lipid Metabolism and Toxicity
	Differentiation of white and brown adipocyte
	Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
	Transcriptional Regulation of White Adipocyte Differentiation
	Adipogenesis
	SREBP signalling
	Nuclear ReceptorsWP299:Nuclear Receptors in Lipid Metabolism and Toxicity
	Nuclear Receptors Meta-Pathway
	Estrogen Receptor Pathway
	PPAR Alpha Pathway
	YAP1- and WWTR1 (TAZ)-stimulated gene expression
	Activation of Gene Expression by SREBP (SREBF)
	SREBF and miR33 in cholesterol and lipid homeostasis
	Circadian Clock
	Nuclear Receptors
References
Ref 532486	Pharmacokinetics, safety, and tolerability of saroglitazar (ZYH1), a predominantly PPARalpha agonist with moderate PPARgamma agonist activity in healthy human subjects. Clin Drug Investig. 2013 Nov;33(11):809-16.
Ref 532486	Pharmacokinetics, safety, and tolerability of saroglitazar (ZYH1), a predominantly PPARalpha agonist with moderate PPARgamma agonist activity in healthy human subjects. Clin Drug Investig. 2013 Nov;33(11):809-16.

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