Drug Information

Drug General Information
Drug ID
D0O9TT
Former ID
DNC000908
Drug Name
LY344864
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539329]
Structure
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2D MOL

3D MOL
Formula
C21H22FN3O
InChI
InChI=1S/C21H22FN3O/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26)
InChIKey
GKWHICIUSVVNGX-UHFFFAOYSA-N
PubChem Compound ID
18971832
PubChem Substance ID
31520176, 47510126, 47805601, 50112872, 85209157, 127968483, 135650553, 136351295, 179293680, 225027510, 233254721, 242589192
Target and Pathway
Target(s) 5-hydroxytryptamine 1F receptor Target Info Agonist [534894]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 539329(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 21).
Ref 5348945-Hydroxytryptamine(1F) receptors do not participate in vasoconstriction: lack of vasoconstriction to LY344864, a selective serotonin(1F) receptor agonist in rabbit saphenous vein. J Pharmacol Exp Ther. 1999 Sep;290(3):935-9.

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