Drug General Information
Drug ID
D0O7GU
Former ID
DAP001026
Drug Name
Palifermin
Synonyms
Kepivance; Kepivance (TN); Palifermin (USAN/INN)
Indication Oral mucositis [ICD9: 528; ICD10:K12.3] Approved [536838], [541990]
Therapeutic Class
Antimucositis Agents
Formula
C721H1142N202O204S9
CAS Number
CAS 162394-19-6
PubChem Substance ID
SuperDrug ATC ID
V03AF08
Target and Pathway
Target(s) Fibroblast growth factor receptor 2 Target Info Binder [537352]
KEGG Pathway MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Signaling pathways regulating pluripotency of stem cells
Regulation of actin cytoskeleton
Pathways in cancer
Prostate cancer
Central carbon metabolism in cancer
NetPath Pathway IL1 Signaling Pathway
PANTHER Pathway FGF signaling pathway
Pathway Interaction Database FGF signaling pathway
Reactome Activated point mutants of FGFR2
WikiPathways Regulation of Actin Cytoskeleton
Ectoderm Differentiation
Hair Follicle Development: Organogenesis (Part 2 of 3)
Hair Follicle Development: Induction (Part 1 of 3)
Cardiac Hypertrophic Response
Signaling Pathways in Glioblastoma
Neural Crest Differentiation
Signaling by FGFR
MicroRNAs in cardiomyocyte hypertrophy
Angiogenesis
References
Ref 536838Emerging drugs for chemotherapy-induced mucositis. Expert Opin Emerg Drugs. 2008 Sep;13(3):511-22.
Ref 541990(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6954).
Ref 537352Keratinocyte growth factor. Expert Opin Biol Ther. 2009 Jun;9(6):779-87.

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