Drug General Information
Drug ID	D0O7DB
Former ID	DIB007016
Drug Name	A-204176
Indication	Stress urinary incontinence [ICD10:N39.3]		Terminated	[547179]
Company	Abbott Laboratories
Structure		Download 2D MOL 3D MOL
Canonical SMILES	S(=O)(=O)(Nc1c2c(C(c3[nH]cnc3)CCC2)ccc1)C
CAS Number	CAS 258527-44-5
Target and Pathway
Target(s)	Alpha-1A adrenergic receptor	Target Info	Agonist	[526245]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	AMPK signaling pathway
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Salivary secretion
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
Reactome	Adrenoceptors
	G alpha (q) signalling events
	G alpha (12/13) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Endothelin Pathways
	GPCR ligand binding
	GPCR downstream signaling
	AMPK Signaling
References
Ref 547179	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013646)
Ref 526245	Pharmacological properties of A-204176, a novel and selective alpha1A adrenergic agonist, in in vitro and in vivo models of urethral function. Life Sci. 2001 Nov 30;70(2):181-97.

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