Drug Information

Drug General Information
Drug ID
D0O6ZO
Former ID
DIB006571
Drug Name
TAK-715
Synonyms
P38 MAP kinase inhibitor (rheumatoid arthritis), Takeda
Drug Type
Small molecular drug
Indication Rheumatoid arthritis [ICD9: 710-719, 714; ICD10:M05-M06] Phase 2 [522447]
Company
Takeda Pharmaceutical Co Ltd
Structure
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2D MOL

3D MOL
Formula
C24H21N3OS
Canonical SMILES
c1(c(sc(n1)CC)c1cc(NC(=O)c2ccccc2)ncc1)c1cc(ccc1)C
PubChem Compound ID
9952773
Target and Pathway
Target(s) Stress kinase p38 Target Info Inhibitor [531443]
References
Ref 522447ClinicalTrials.gov (NCT00760864) Safety and Efficacy of TAK-715 in Subjects With Rheumatoid Arthritis. U.S. National Institutes of Health.
Ref 531443Inhibition of Wnt/beta-catenin signaling by p38 MAP kinase inhibitors is explained by cross-reactivity with casein kinase Idelta/?. Chem Biol. 2011 Apr 22;18(4):485-94.

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