| Drug General Information |
| Drug ID |
D0O5KK
|
| Former ID |
DNC008397
|
| Drug Name |
7,8,9,10-tetrahydro-6H-furo-[2,3-g][3]benzazepine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C12H13NO
|
| Canonical SMILES |
C1CNCCC2=C1C=CC3=C2OC=C3
|
| InChI |
1S/C12H13NO/c1-2-10-5-8-14-12(10)11-4-7-13-6-3-9(1)11/h1-2,5,8,13H,3-4,6-7H2
|
| InChIKey |
QDAAIWYKQLAISZ-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
5-hydroxytryptamine 2C receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| 5-hydroxytryptamine 2B receptor |
Target Info |
Inhibitor |
[1]
|
| 5-hydroxytryptamine 2A receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Gap junction
|
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Serotonergic synapse
|
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Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
|
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Inflammatory mediator regulation of TRP channels
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PANTHER Pathway
|
5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
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|
Reactome
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Serotonin receptors
|
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G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
|
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G alpha (q) signalling events
|
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WikiPathways
|
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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Gastrin-CREB signalling pathway via PKC and MAPK
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GPCR ligand binding
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GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
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GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
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SIDS Susceptibility Pathways
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|
GPCR downstream signaling
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|
GPCRs, Other
|
| References |
| REF 1 | Bioorg Med Chem. 2008 Mar 15;16(6):3309-20. Epub 2007 Dec 8.Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists. |
|---|
