Drug General Information
Drug ID	D0O5FK
Former ID	DNC006476
Drug Name	2-(4-(methylamino)phenyl)benzo[d]thiazol-6-ol
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528161]
Structure		Download 2D MOL 3D MOL
Formula	C14H12N2OS
Canonical SMILES	CNC1=CC=C(C=C1)C2=NC3=C(S2)C=C(C=C3)O
InChI	1S/C14H12N2OS/c1-15-10-4-2-9(3-5-10)14-16-12-7-6-11(17)8-13(12)18-14/h2-8,15,17H,1H3
InChIKey	ZQAQXZBSGZUUNL-UHFFFAOYSA-N
PubChem Compound ID	10171487
Target and Pathway
Target(s)	Amyloid beta A4 protein	Target Info	Inhibitor	[528161]
KEGG Pathway	Notch signaling pathway
	Alzheimer's disease
Reactome	Nuclear signaling by ERBB4
	Degradation of the extracellular matrix
	Regulated proteolysis of p75NTR
	NRIF signals cell death from the nucleus
	Activated NOTCH1 Transmits Signal to the Nucleus
	Constitutive Signaling by NOTCH1 PEST Domain Mutants
	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	EPH-ephrin mediated repulsion of cells
WikiPathways	Notch Signaling Pathway
	Signaling by ERBB4
	Signaling by NOTCH3
	Signaling by NOTCH4
	Signaling by NOTCH1
	Signaling by NOTCH2
	Notch Signaling Pathway
	Alzheimers Disease
	Signalling by NGF
References
Ref 528161	J Med Chem. 2006 May 4;49(9):2841-4.Synthesis of biphenyltrienes as probes for beta-amyloid plaques.
Ref 528161	J Med Chem. 2006 May 4;49(9):2841-4.Synthesis of biphenyltrienes as probes for beta-amyloid plaques.

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