Drug Information

Drug General Information
Drug ID
D0O4XW
Former ID
DCL000190
Drug Name
ONO-4819
Synonyms
Rivenprost; AE1-734; ONO-4819CD; ONO-4819.CD; ONO-AE1-734
Drug Type
Small molecular drug
Indication Fracture [ICD10:M48.5] Discontinued in Phase 2 [539230], [547505]
Company
Novartis
Structure
Download
2D MOL

3D MOL
Formula
C24H34O6S
InChI
InChI=1S/C24H34O6S/c1-29-16-18-6-3-5-17(13-18)14-19(25)8-9-20-21(23(27)15-22(20)26)10-12-31-11-4-7-24(28)30-2/h3,5-6,8-9,13,19-22,25-26H,4,7,10-12,14-16H2,1-2H3/b9-8+/t19-,20-,21-,22-/m1/s1
InChIKey
FBQUXLIJKPWCAO-AZIFJQEOSA-N
PubChem Compound ID
9803828
PubChem Substance ID
14759910, 14759911, 24112125, 44839825, 49684223, 79732123, 103254076, 104153232, 134338859, 135253526, 135650764, 142211462, 198953089, 228431315
Target and Pathway
Target(s) Prostaglandin E2 receptor, EP4 subtype Target Info Agonist [536219], [536465], [537179]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancer
NetPath Pathway FSH Signaling Pathway
IL2 Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539230(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1930).
Ref 547505Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016907)
Ref 536219Effects on improvement of blood flow in the chronically compressed cauda equina: comparison between a selective prostaglandin E receptor (EP4) agonist and a prostaglandin E1 derivate. Spine (Phila Pa1976). 2006 Apr 15;31(8):869-72.
Ref 536465Prostaglandin E2 EP4 agonist (ONO-4819) accelerates BMP-induced osteoblastic differentiation. Bone. 2007 Oct;41(4):543-8. Epub 2007 Jun 29.
Ref 537179Effect of a prostaglandin EP4 receptor agonist on early fixation of hydroxyapatite/titanium composite- and titanium-coated rough-surfaced implants in ovariectomized rats. J Biomed Mater Res A. 2009 Mar 25.

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