Drug General Information
Drug ID	D0O0BM
Former ID	DIB004645
Drug Name	PF-3463275
Synonyms	PF-03463275
Indication	Schizophrenia [ICD9: 295; ICD10:F20]		Phase 2	[522783]
Company	Pfizer Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c1c(ncn1C)C(=O)N(C[C@@H]1[C@H]2CN(C[C@@H]12)C)Cc1cc(c(c<br />c1)F)Cl
Target and Pathway
Target(s)	Sodium- and chloride-dependent glycine transporter 1	Target Info	Inhibitor	[532527]
Reactome	Na+/Cl- dependent neurotransmitter transporters
WikiPathways	NRF2 pathway
References
Ref 522783	ClinicalTrials.gov (NCT00977522) A Study Of PF-03463275 As Add-On Therapy In Outpatients With Persistent Negative Symptoms Of Schizophrenia. U.S. National Institutes of Health.
Ref 532527	Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and pain. Nat Rev Drug Discov. 2013 Nov;12(11):866-85.

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