Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0NU0U
|
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| Former ID |
DNCL002653
|
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| Drug Name |
AZD4547
|
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| Drug Type |
Small molecular drug
|
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| Company |
AstraZeneca
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C26H33N5O3
|
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| InChI |
InChI=1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21(29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8,15-16H2,1-4H3,(H2,28,29,30,32)/t17-,18+
|
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| InChIKey |
VRQMAABPASPXMW-HDICACEKSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
117699613, 135610501, 136340324, 136350053, 136920281, 136970544, 140819315, 144115667, 152159627, 163643100, 164041821, 172918164, 174006594, 174525910, 185997025, 190361859, 193883042, 198940588, 223366040, 223367238, 223404365, 223436471, 223471434, 223702523, 224188020, 226445213, 240205758, 241383730, 242587692, 248906639, 249818642, 249869575, 252110149, 252160568, 252442834, 252451807, 252470587
|
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| Target and Pathway | |||||
| Target(s) | Basic fibroblast growth factor receptor 1 | Target Info | Modulator | [531819] | |
| KEGG Pathway | MAPK signaling pathway | ||||
| Ras signaling pathway | |||||
| Rap1 signaling pathway | |||||
| PI3K-Akt signaling pathway | |||||
| Adherens junction | |||||
| Signaling pathways regulating pluripotency of stem cells | |||||
| Regulation of actin cytoskeleton | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| Prostate cancer | |||||
| Melanoma | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| FGF signaling pathway | |||||
| Pathway Interaction Database | Glypican 1 network | ||||
| Syndecan-4-mediated signaling events | |||||
| N-cadherin signaling events | |||||
| FGF signaling pathway | |||||
| References | |||||
| Ref 524785 | ClinicalTrials.gov (NCT02154490) Lung-MAP: S1400 Biomarker-Targeted Second-Line Therapy in Treating Patients With Recurrent Stage IIIB-IV Squamous Cell Lung Cancer. U.S. National Institutes of Health. | ||||
| Ref 542682 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7707). | ||||
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