Drug Information

Drug General Information
Drug ID
D0NS6H
Former ID
DIB013501
Drug Name
Donepezil
Synonyms
Donepezil (transdermal patch, Alzheimer's disease)
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Approved [541717], [544878], [551871]
Therapeutic Class
Neurology Agents
Company
Nitto Denko Corp
Structure
Download
2D MOL

3D MOL
Formula
C24H29NO3
InChI
InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3
InChIKey
ADEBPBSSDYVVLD-UHFFFAOYSA-N
PubChem Compound ID
3152
PubChem Substance ID
4396592, 7979121, 8152007, 11364558, 11367120, 11369682, 11377844, 11495478, 14829295, 29222294, 46504803, 46509735, 47526357, 47673582, 49830545, 49982851, 50112790, 50803390, 57321637, 81041121, 85730950, 92711664, 96024565, 103172342, 103853425, 104302675, 104825734, 121264514, 121291395, 125333679, 126525333, 126584296, 126584297, 126630639, 126657167, 126663241, 126670558, 127318381, 127318382, 127318383, 127318384, 127318385, 127318386, 127318387, 127318388, 127318389, 127318390, 127318391, 127318392, 127318393
Target and Pathway
Target(s) Acetylcholinesterase Target Info Modulator [543634]
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PathWhiz Pathway Phospholipid Biosynthesis
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
Ref 541717(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6599).
Ref 544878Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001402)
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 543634(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2465).

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