Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0NN5F
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| Former ID |
DIB009360
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| Drug Name |
BChE inhibitors
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| Synonyms |
BChE inhibitors (imaging, Alzheimers disease); BChE inhibitors (imaging, Alzheimers disease), University ofNebraska Medical Center; Imaging/therapeutic butyrylcholinesterase inhibitors (Alzheimers disease), UNMC
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| Indication | Alzheimer disease [ICD9: 331; ICD10:G30] | Investigative | [1] | ||
| Company |
University of Nebraska Medical Center
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| Structure |
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Download2D MOL |
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| Canonical SMILES |
[nH]1c(=O)n(cc(c1=O)C)[C@H]1C[C@@H]([C@H](O1)COP1(=O)Oc<br />2c(cc(c(c2CO1)F)C(C)(C)C)C(C)(C)C)[18F]
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| Target and Pathway | |||||
| Target(s) | Cholinesterase | Target Info | Inhibitor | [2] | |
| PANTHER Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | ||||
| Muscarinic acetylcholine receptor 2 and 4 signaling pathway | |||||
| Nicotinic acetylcholine receptor signaling pathway | |||||
| WikiPathways | Irinotecan Pathway | ||||
| References | |||||
| REF 1 | Screening assays for cholinesterases resistant to inhibition by organophosphorus toxicants. Anal Biochem. 2004 Jun 1;329(1):131-8. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2471). | ||||
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