Drug Information

Drug General Information
Drug ID
D0N9WB
Former ID
DNC000236
Drug Name
APC-366
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Discontinued in Phase 2 [545523]
Structure
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2D MOL

3D MOL
Formula
C22H29ClN6O4
Canonical SMILES
C1CC(N(C1)C(=O)C(CCCN=C(N)N)NC(=O)C2=C(C3=CC=CC=C3C=C2)<br />O)C(=O)N.Cl
InChI
1S/C22H28N6O4.ClH/c23-19(30)17-8-4-12-28(17)21(32)16(7-3-11-26-22(24)25)27-20(31)15-10-9-13-5-1-2-6-14(13)18(15)29;/h1-2,5-6,9-10,16-17,29H,3-4,7-8,11-12H2,(H2,23,30)(H,27,31)(H4,24,25,26);1H/t16-,17-;/m0./s1
InChIKey
IZLPTTJTHFFFJF-QJHJCNPRSA-N
CAS Number
CAS 178925-65-0
PubChem Compound ID
177339
PubChem Substance ID
12014836, 14883286, 33500792, 50580856, 57395382, 104426311, 134339714, 135154964, 240594959
Target and Pathway
Target(s) Tryptase Target Info Inhibitor [534849]
Reactome Activation of Matrix Metalloproteinases
References
Ref 545523Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003595)
Ref 534849Inhibitors of tryptase for the treatment of mast cell-mediated diseases. Curr Pharm Des. 1998 Oct;4(5):381-96.

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