Drug General Information
Drug ID	D0N7WB
Former ID	DIB013449
Drug Name	CLR-151
Synonyms	CLR-100 series; CLR-136; CLR-155; CLR-161
Indication	Psychotic disorders [ICD9: 290-299; ICD10:F20-F29]		Investigative	[543559]
Company	Clera Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	C(CC(=O)c1cccc(c1)OC)CN1CCC(CC1)(c1ccc(cc1)Cl)O
Target and Pathway
Target(s)	D(2) dopamine receptor	Target Info	Antagonist	[543559]
KEGG Pathway	Rap1 signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Alcoholism
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathway
Reactome	Dopamine receptors
	G alpha (i) signalling events
WikiPathways	Hypothetical Network for Drug Addiction
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Genes and (Common) Pathways Underlying Drug Addiction
	GPCR ligand binding
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic Neurons
References
Ref 543559	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 215).
Ref 543559	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 215).

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