Drug Information

Drug General Information
Drug ID
D0N7LZ
Former ID
DNC003924
Drug Name
SK&F-104856
Synonyms
SK-104856
Drug Type
Small molecular drug
Indication Discovery agent Terminated [544924]
Structure
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2D MOL

3D MOL
Formula
C14H14ClNS
Canonical SMILES
CN1CCC2=C(C=CC3=C2C(=C(S3)C=C)C1)Cl
InChI
1S/C14H14ClNS/c1-3-12-10-8-16(2)7-6-9-11(15)4-5-13(17-12)14(9)10/h3-5H,1,6-8H2,2H3
InChIKey
WKXSXFYQPCWZOS-UHFFFAOYSA-N
PubChem Compound ID
126225
Target and Pathway
Target(s) Alpha-1D adrenergic receptor Target Info Inhibitor [533638]
Alpha-1A adrenergic receptor Target Info Inhibitor [533638]
Alpha-1B adrenergic receptor Target Info Inhibitor [533638]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretionhsa04020:Calcium signaling pathway
AMPK signaling pathway
Salivary secretion
NetPath Pathway IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Pathway Interaction Database LPA receptor mediated events
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP58:Monoamine GPCRs
Endothelin Pathways
AMPK SignalingWP58:Monoamine GPCRs
Vitamin D Receptor Pathway
AMPK Signaling
References
Ref 544924Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001560)
Ref 533638J Med Chem. 1995 Sep 15;38(19):3681-716.Alpha- and beta-adrenoceptors: from the gene to the clinic. 2. Structure-activity relationships and therapeutic applications.

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