Drug General Information
Drug ID
D0N6SO
Former ID
DCL000647
Drug Name
SYR-472
Drug Type
Small molecular drug
Indication Metabolic disorders [ICD9: 270-279; ICD10:E70-E89] Phase 3 [551987]
Company
Takeda
Structure
Download
2D MOL

3D MOL

Formula
C22H26FN5O6
Canonical SMILES
CN1C(=O)C=C(N(C1=O)CC2=C(C=CC(=C2)F)C#N)N3CCCC(C3)N.C(C<br />C(=O)O)C(=O)O
InChI
1S/C18H20FN5O2.C4H6O4/c1-22-17(25)8-16(23-6-2-3-15(21)11-23)24(18(22)26)10-13-7-14(19)5-4-12(13)9-20;5-3(6)1-2-4(7)8/h4-5,7-8,15H,2-3,6,10-11,21H2,1H3;1-2H2,(H,5,6)(H,7,8)/t15-;/m1./s1
InChIKey
OGCNTTUPLQTBJI-XFULWGLBSA-N
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
R03AC09
SuperDrug CAS ID
cas=018559596
Target and Pathway
Target(s) Dipeptidyl peptidase IV Target Info Inhibitor [532703], [551717]
KEGG Pathway Protein digestion and absorption
NetPath Pathway IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
References
Ref 551987Clinical pipeline report, company report or official report of Takeda.
Ref 532703SYR-472, a novel once-weekly dipeptidyl peptidase-4 (DPP-4) inhibitor, in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol. 2014 Feb;2(2):125-32.
Ref 551717Clinical pipeline report, company report or official report of Takeda (2009).

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