Drug General Information
Drug ID	D0N4PW
Former ID	DIB008148
Drug Name	iOWH032
Synonyms	CFTR inhibitors (diarrhea); IOWH-032; CFTR inhibitors (diarrhea), BioFocus
Indication	Diarrhea [ICD9: 787.91; ICD10:A09, K59.1]		Phase 2	[524714]
Company	The Institute for OneWorld Health
Structure		Download 2D MOL 3D MOL
Canonical SMILES	o1nc(nc1C(=O)NCc1ccc(cc1)Oc1ccccc1)c1cc(c(c(c1)Br)O)Br
Target and Pathway
Target(s)	cystic fibrosis transmembrane conductance regulator	Target Info	Inhibitor	[531605]
KEGG Pathway	ABC transporters
	cAMP signaling pathway
	AMPK signaling pathway
	Gastric acid secretion
	Pancreatic secretion
	Bile secretion
	Vibrio cholerae infection
Reactome	ABC-family proteins mediated transport
WikiPathways	ABC-family proteins mediated transport
References
Ref 524714	ClinicalTrials.gov (NCT02111304) Efficacy of iOWH032 in Dehydrating Cholera. U.S. National Institutes of Health.
Ref 531605	Developing novel antisecretory drugs to treat infectious diarrhea. Future Med Chem. 2011 Aug;3(10):1317-25.

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