Drug Information

Drug General Information
Drug ID
D0N3VR
Former ID
DAP001271
Drug Name
Voriconazole
Synonyms
VCZ; Vfend; Pfizer brand of voriconazole; UK 109496; Voriconazole in combination with MGCD290; DRG-0301; UK 109,496; UK-109496; VFEND (TN); Vfend (TN); Vfend, Voriconazole; UK-109,496; Voriconazole [USAN:INN:BAN]; Voriconazole (JAN/USAN/INN); (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol; (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; (R-(R*,S*))-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol; (alphaR,betaS)-alpha-(2,4-Difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol; (alphaR,betaS)-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol; VRC
Drug Type
Small molecular drug
Indication Invasive aspergillosis [ICD9: 117.3; ICD10:B44] Approved [537601]
Therapeutic Class
Antifungal Agents
Company
Pfizer
Structure
Download
2D MOL

3D MOL
Formula
C16H14F3N5O
Canonical SMILES
CC(C1=NC=NC=C1F)C(CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O
InChI
1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1
InChIKey
BCEHBSKCWLPMDN-MGPLVRAMSA-N
CAS Number
CAS 137234-62-9
PubChem Compound ID
71616
PubChem Substance ID
9824, 618929, 7847644, 8194731, 12014673, 14754154, 14900759, 26719857, 43127923, 46386721, 46506421, 49681678, 49830865, 50065685, 53790739, 57318277, 58107314, 79258320, 92308499, 92712543, 93165418, 99437153, 103042056, 103188976, 104350892, 109692905, 117510444, 118048601, 121361066, 124658937, 124757251, 124766492, 125083219, 125164055, 126592905, 126625471, 126656629, 126670609, 127494461, 134338507, 135029377, 136340251, 136367733, 137006421, 140298163, 144076218, 144205794, 152164501, 160870955, 160963927
SuperDrug ATC ID
J02AC03
SuperDrug CAS ID
cas=137234629
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) Fungal Cytochrome P450 51 Target Info Modulator [556264]
References
Ref 537601Disk diffusion test and E-test with enriched Mueller-Hinton agar for determining susceptibility of Candida species to voriconazole and fluconazole. J Microbiol Immunol Infect. 2009 Apr;42(2):148-53.
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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