Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0N2XO
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| Former ID |
DNC007231
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| Drug Name |
2-(3-methoxyphenyl)-6-morpholino-4H-pyran-4-one
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [528738] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C16H17NO4
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| Canonical SMILES |
COC1=CC=CC(=C1)C2=CC(=O)C=C(O2)N3CCOCC3
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| InChI |
1S/C16H17NO4/c1-19-14-4-2-3-12(9-14)15-10-13(18)11-16(21-15)17-5-7-20-8-6-17/h2-4,9-11H,5-8H2,1H3
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| InChIKey |
OLIONIBTYZDPMY-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | DNA-dependent protein kinase catalytic subunit | Target Info | Inhibitor | [528738] | |
| KEGG Pathway | Non-homologous end-joining | ||||
| Cell cycle | |||||
| NetPath Pathway | IL1 Signaling Pathway | ||||
| Reactome | Nonhomologous End-Joining (NHEJ) | ||||
| References | |||||
| Ref 528738 | J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase. | ||||
| Ref 528738 | J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase. | ||||
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