Drug Information

Drug General Information
Drug ID
D0N1FR
Former ID
DIB000470
Drug Name
BECATECARIN
Synonyms
BMS-181176; Becatecarin < USAN; DEAE-Rebeccamycin; Prop INN >; XL-119; BMY-27557-01 (HCl); BMY-27557-14 (tartrate); 1,11-Dichloro-6-[2-(diethylamino)ethyl]-12-(4-O-methyl-beta-D-glucopyranosyl)-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Discontinued in Phase 3 [549905]
Company
Exelixis
Structure
Download
2D MOL

3D MOL
Formula
C33H34Cl2N4O7
Canonical SMILES
CCN(CC)CCN1C(=O)c2c(C1=O)c3c4cccc(Cl)c4n([C@@H]5O[C@H](<br />CO)[C@@H](OC)[C@H](O)[C@H]5O)c3c6[nH]c7c(Cl)cccc7c26
InChI
1S/C33H34Cl2N4O7/c1-4-37(5-2)12-13-38-31(43)22-20-15-8-6-10-17(34)24(15)36-25(20)27-21(23(22)32(38)44)16-9-7-11-18(35)26(16)39(27)33-29(42)28(41)30(45-3)19(14-40)46-33/h6-11,19,28-30,33,36,40-42H,4-5,12-14H2,1-3H3/t19-,28-,29-,30-,33-/m1/s1
InChIKey
JSKFWUPVIZYJMR-UDOAKELVSA-N
CAS Number
CAS 119673-08-4
PubChem Compound ID
101524
Target and Pathway
Target(s) Toposisomerase-1 Target Info Modulator [1572591]
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway DNA replication
Pathway Interaction Database Caspase Cascade in Apoptosis
WikiPathways Integrated Pancreatic Cancer Pathway
References
Ref 549905Clinical pipeline report, company report or official report of Exelixis.
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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