Drug General Information
Drug ID	D0N0LZ
Former ID	DNC012099
Drug Name	3-Naphthalen-1-yl-pyrrolidine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[551334]
Structure		Download 2D MOL 3D MOL
Formula	C14H15N
Canonical SMILES	C1CNCC1C2=CC=CC3=CC=CC=C32
InChI	1S/C14H15N/c1-2-6-13-11(4-1)5-3-7-14(13)12-8-9-15-10-12/h1-7,12,15H,8-10H2
InChIKey	KTMCVZGLGDBGJZ-UHFFFAOYSA-N
PubChem Compound ID	10584082
Target and Pathway
Target(s)	D(2) dopamine receptor	Target Info	Inhibitor	[551334]
	5-hydroxytryptamine 2A receptor	Target Info	Inhibitor	[551334]
	5-hydroxytryptamine 1A receptor	Target Info	Inhibitor	[551334]
KEGG Pathway	Rap1 signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Dopaminergic synapse
	Parkinson's disease
	Cocaine addiction
	Alcoholismhsa04020:Calcium signaling pathway
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Dopamine receptor mediated signaling pathway
	Nicotine pharmacodynamics pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	5HT1 type receptor mediated signaling pathway
Reactome	Dopamine receptors
	G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (i) signalling events
WikiPathways	Hypothetical Network for Drug Addiction
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Genes and (Common) Pathways Underlying Drug Addiction
	GPCR ligand binding
	GPCR downstream signaling
	Nicotine Activity on Dopaminergic NeuronsWP733:Serotonin Receptor 2 and STAT3 Signaling
	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	SIDS Susceptibility Pathways
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
References
Ref 551334	Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity, Bioorg. Med. Chem. Lett. 7(3):241-246 (1997).
Ref 551334	Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity, Bioorg. Med. Chem. Lett. 7(3):241-246 (1997).

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