| Drug General Information |
| Drug ID |
D0N0LZ
|
| Former ID |
DNC012099
|
| Drug Name |
3-Naphthalen-1-yl-pyrrolidine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C14H15N
|
| Canonical SMILES |
C1CNCC1C2=CC=CC3=CC=CC=C32
|
| InChI |
1S/C14H15N/c1-2-6-13-11(4-1)5-3-7-14(13)12-8-9-15-10-12/h1-7,12,15H,8-10H2
|
| InChIKey |
KTMCVZGLGDBGJZ-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
D(2) dopamine receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| 5-hydroxytryptamine 2A receptor |
Target Info |
Inhibitor |
[1]
|
| 5-hydroxytryptamine 1A receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Rap1 signaling pathway
|
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cAMP signaling pathway
|
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Neuroactive ligand-receptor interaction
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Gap junction
|
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Dopaminergic synapse
|
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Parkinson's disease
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Cocaine addiction
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Alcoholismhsa04020:Calcium signaling pathway
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Serotonergic synapse
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Inflammatory mediator regulation of TRP channelshsa04024:cAMP signaling pathway
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
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Dopamine receptor mediated signaling pathway
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Nicotine pharmacodynamics pathwayP04374:5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
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5HT1 type receptor mediated signaling pathway
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Reactome
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Dopamine receptors
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G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
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G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
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G alpha (i) signalling events
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WikiPathways
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Hypothetical Network for Drug Addiction
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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Genes and (Common) Pathways Underlying Drug Addiction
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GPCR ligand binding
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GPCR downstream signaling
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Nicotine Activity on Dopaminergic NeuronsWP733:Serotonin Receptor 2 and STAT3 Signaling
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Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
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SIDS Susceptibility Pathways
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Gastrin-CREB signalling pathway via PKC and MAPK
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GPCRs, OtherWP722:Serotonin HTR1 Group and FOS Pathway
|
| References |
| REF 1 | Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity, Bioorg. Med. Chem. Lett. 7(3):241-246 (1997). |
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