Drug Information
Drug General Information | |||||
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Drug ID |
D0N0LN
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Former ID |
DIB020816
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Drug Name |
RN486
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Synonyms |
RN-486; compound 29 [PMID 22394077]
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [531761] | ||
Structure |
Download2D MOL |
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Formula |
C35H35FN6O3
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InChI |
InChI=1S/C35H35FN6O3/c1-39-12-14-41(15-13-39)26-8-9-32(37-19-26)38-30-18-25(20-40(2)34(30)44)27-4-3-5-31(28(27)21-43)42-11-10-23-16-24(22-6-7-22)17-29(36)33(23)35(42)45/h3-5,8-11,16-20,22,43H,6-7,12-15,21H2,1-2H3,(H,37,38)
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InChIKey |
ZTUJNJAKTLHBEX-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Tyrosine-protein kinase BTK | Target Info | Inhibitor | [531761] | |
STE20-like kinase | Target Info | Inhibitor | [531761] | ||
PANTHER Pathway | B cell activation | ||||
PathWhiz Pathway | Fc Epsilon Receptor I Signaling in Mast Cells | ||||
Reactome | MyD88:Mal cascade initiated on plasma membrane | ||||
Regulation of actin dynamics for phagocytic cup formation | |||||
DAP12 signaling | |||||
FCERI mediated Ca+2 mobilization | |||||
MyD88 deficiency (TLR2/4) | |||||
IRAK4 deficiency (TLR2/4) | |||||
RHO GTPases Activate WASPs and WAVEs | |||||
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | |||||
References |
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