Drug General Information
Drug ID	D0N0JE
Former ID	DIB004014
Drug Name	UP-275-22
Indication	Hypertension [ICD9: 401; ICD10:I10-I16]		Terminated	[545814]
Company	Laboratories UPSA
Structure		Download 2D MOL 3D MOL
Canonical SMILES	c12nc(c(c(n1ncn2)CCCC)Cc1ccc(c2c(c3nnn[nH]3)cccc2)cc1)O
CAS Number	CAS 186616-16-0
Target and Pathway
Target(s)	Type-1 angiotensin II receptor	Target Info	Modulator	[543777]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Renin-angiotensin system
	Renin secretion
	Pathways in cancer
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
PANTHER Pathway	Angiotensin II-stimulated signaling through G proteins and beta-arrestin
Pathway Interaction Database	Arf6 trafficking events
	Arf6 signaling events
	Angiopoietin receptor Tie2-mediated signaling
PathWhiz Pathway	Angiotensin Metabolism
	Muscle/Heart Contraction
Reactome	Peptide ligand-binding receptors
	G alpha (q) signalling events
WikiPathways	ACE Inhibitor Pathway
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	Allograft Rejection
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545814	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004864)
Ref 543777	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 34).

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