Drug General Information
Drug ID
D0N0ED
Former ID
DIB020578
Drug Name
NTE-2
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533271]
Structure
Download
2D MOL
Formula
C44H54FN5O4
InChI
InChI=1S/C44H54FN5O4/c1-54-44(53)48-29-35(26-32-25-34-15-8-9-17-40(34)47-28-32)37-27-31(20-23-38(37)45)12-5-2-4-11-30-18-21-36(22-19-30)49-42(51)41(33-13-6-3-7-14-33)50-24-10-16-39(46)43(50)52/h8-9,15,17-23,25,27-28,33,35,39,41H,2-7,10-14,16,24,26,29,46H2,1H3,(H,48,53)(H,49,51)/t35-,39+,41+/m1/s1
InChIKey
SDVPSGCYRLUZSS-WXSHXSFMSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Insulin-degrading Enzyme Target Info Inhibitor [533271]
KEGG Pathway Alzheimer's disease
WikiPathways Alzheimers Disease
References
Ref 533271Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. J Biol Chem. 2015 Aug 14;290(33):20044-59.
Ref 533271Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo. J Biol Chem. 2015 Aug 14;290(33):20044-59.

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