| Drug General Information |
| Drug ID |
D0MU4A
|
| Former ID |
DIB020976
|
| Drug Name |
spiroxatrine
|
| Synonyms |
spiroxamide
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
|
| Formula |
C22H25N3O3
|
| InChI |
InChI=1S/C22H25N3O3/c26-21-22(25(16-23-21)17-6-2-1-3-7-17)10-12-24(13-11-22)14-18-15-27-19-8-4-5-9-20(19)28-18/h1-9,18H,10-16H2,(H,23,26)
|
| InChIKey |
JVGBTTIJPBFLTE-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
239745, 511095, 5614464, 8153239, 11426887, 14902387, 17405698, 24278126, 26751807, 26751808, 29224323, 48035367, 48259474, 48334741, 50064107, 50104500, 50104501, 53778248, 57322687, 76693065, 85089532, 85209933, 85231214, 85788304, 90341505, 91746427, 92303168, 92308813, 103249514, 103931109, 104171234, 104308748, 121361869, 124750267, 124881358, 124881359, 124881360, 126408104, 128332426, 135028248, 135651066, 135697853, 137010278, 137263948, 138809382, 142936465, 144203811, 162022505, 162090868, 163138086
|
| Target and Pathway |
| Target(s) |
5-hydroxytryptamine 1A receptor |
Target Info |
Agonist |
[2]
|
|---|
| 5-hydroxytryptamine 2B receptor |
Target Info |
Antagonist |
[3]
|
| Alpha-2B adrenergic receptor |
Target Info |
Antagonist |
[4]
|
| Alpha-2C adrenergic receptor |
Target Info |
Antagonist |
[5]
|
| Alpha-1B adrenergic receptor |
Target Info |
Antagonist |
[5]
|
|
KEGG Pathway
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cAMP signaling pathway
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Neuroactive ligand-receptor interaction
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Serotonergic synapsehsa04020:Calcium signaling pathway
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Gap junction
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Serotonergic synapse
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Inflammatory mediator regulation of TRP channelshsa04022:cGMP-PKG signaling pathway
|
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Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
|
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Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
|
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cGMP-PKG signaling pathway
|
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Adrenergic signaling in cardiomyocytes
|
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Vascular smooth muscle contraction
|
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Salivary secretion
|
|
NetPath Pathway
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IL2 Signaling Pathway
|
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PANTHER Pathway
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
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5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
|
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Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
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Pathway Interaction Database
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LPA receptor mediated events
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|
Reactome
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Serotonin receptors
|
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G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
|
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G alpha (q) signalling eventsR-HSA-390696:Adrenoceptors
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Adrenaline signalling through Alpha-2 adrenergic receptor
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G alpha (i) signalling events
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G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
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Adrenaline,noradrenaline inhibits insulin secretion
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G alpha (z) signalling events
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Surfactant metabolismR-HSA-390696:Adrenoceptors
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G alpha (q) signalling events
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G alpha (12/13) signalling events
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WikiPathways
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Serotonin HTR1 Group and FOS Pathway
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SIDS Susceptibility Pathways
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Monoamine GPCRs
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GPCRs, Class A Rhodopsin-like
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GPCR ligand binding
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GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
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Gastrin-CREB signalling pathway via PKC and MAPK
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GPCR downstream signalingWP58:Monoamine GPCRs
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Platelet Aggregation (Plug Formation)
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Integration of energy metabolism
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Calcium Regulation in the Cardiac Cell
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Vitamin D Receptor Pathway
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GPCR downstream signaling
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AMPK Signaling
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| References |
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 53). |
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| REF 2 | Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study. Eur J Pharmacol. 1998 Aug 21;355(2-3):245-56. |
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| REF 3 | [3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):17-24. |
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| REF 4 | The novel alpha-2 adrenergic radioligand [3H]-MK912 is alpha-2C selective among human alpha-2A, alpha-2B and alpha-2C adrenoceptors. J Pharmacol Exp Ther. 1994 Dec;271(3):1558-65. |
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| REF 5 | Affinity of serotonin receptor antagonists and agonists to recombinant and native alpha1-adrenoceptor subtypes. Jpn J Pharmacol. 2001 Jun;86(2):189-95. |
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