Drug Information

Drug General Information
Drug ID
D0ML1F
Former ID
DAP000060
Drug Name
Adefovir Dipivoxil
Synonyms
Adefovirdipivoxl; Hepsera; Preveon; YouHeDing; Adefovir depivoxil; Adefovir pivoxil; GS 0840; GS 840;Piv2PMEA; Adefovir dipivoxil (USAN); Adefovir pivoxil (JAN); Bis(pom)PMEA; Bis-POM PMEA; GS-0840; GS-840; Hepsera (TM); Hepsera (TN); Preveon (TN); Bis(POM)-PMEA; Bis-POM PMEA, Adefovir Dipivoxil; Bis-POM PMEA, Preveon, Hepsera, Adefovir Dipivoxil; Bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine; [2-(6-aminopurin-9-yl)ethoxymethyl-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate; Propanoic acid,2,2-dimethyl-(((2-(6-amino-9H-purin-9-yl)ehtoxy)mehtyl)phosphinyldiene)bis(oxymehtylene)ester; Propanoic acid, 2,2-dimethyl-, (((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)phosphinylidene)bis(oxymethylene) ester; (((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphinylidene)bis(oxymethylene) 2,2-dimethylpropanoate; ((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid, diester with hydroxymethyl pivalate; 9-(2-((-Bis((pivaloyloxy)methoxy)phosphinyl)methoxy)ethyl)adenine; 9-(2-((Bis((pivaloyloxy)methoxy)phosphinyl)methoxy)ethyl)adenine; ADV
Drug Type
Small molecular drug
Indication HBV infection [ICD9: 070.2-070.3; ICD10:B16, B18.0, B18.1] Approved [536414]
Discovery agent Investigative [1572605]
Therapeutic Class
Antiviral Agents
Company
Gilead Sciences
Structure
Download
2D MOL

3D MOL
Formula
C20H32N5O8P
Canonical SMILES
CC(C)(C)C(=O)OCOP(=O)(COCCN1C=NC2=C1N=CN=C2N)OCOC(=O)C(<br />C)(C)C
InChI
1S/C20H32N5O8P/c1-19(2,3)17(26)30-11-32-34(28,33-12-31-18(27)20(4,5)6)13-29-8-7-25-10-24-14-15(21)22-9-23-16(14)25/h9-10H,7-8,11-13H2,1-6H3,(H2,21,22,23)
InChIKey
WOZSCQDILHKSGG-UHFFFAOYSA-N
CAS Number
CAS 142340-99-6
PubChem Compound ID
60871
PubChem Substance ID
612309, 7848718, 8187107, 11528768, 12014790, 14908863, 26758046, 43118206, 46507520, 49830940, 57314164, 71824987, 74485826, 87244050, 87245424, 92712536, 103240599, 104253333, 104321855, 109692937, 118048871, 119525323, 124757452, 125164256, 125340236, 126592990, 126630083, 126656634, 126665844, 129613204, 131298815, 134222429, 134337388, 134338819, 134340371, 135018282, 135565514, 135692243, 135727110, 136345656, 136368131, 136946538, 136949103, 137006009, 142181502, 143493341, 144115540, 144180310, 144205796, 152242352
SuperDrug ATC ID
J05AF08
SuperDrug CAS ID
cas=142340996
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) HIV reverse transcriptase Target Info Modulator [556264]
References
Ref 536414Telbivudine: a new option for the treatment of chronic hepatitis B. Expert Opin Biol Ther. 2007 May;7(5):751-61.
Ref 1572605The ChEMBL database in 2017.
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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