Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0M6YW
|
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| Former ID |
DIB003027
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| Drug Name |
GYKI-12743
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| Drug Type |
Small molecular drug
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| Indication | Hypertension [ICD9: 401; ICD10:I10-I16] | Discontinued in Phase 1 | [1] | ||
| Company |
Gedeon Richter Ltd
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C16H20ClN3O3
|
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| Canonical SMILES |
n1(c(=O)cccn1)CCCNCC1Oc2c(OC1)cccc2.Cl
|
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| CAS Number |
CAS 110714-10-8
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Alpha-2C adrenergic receptor | Target Info | Modulator | [2] | |
| KEGG Pathway | cGMP-PKG signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| PANTHER Pathway | Alpha adrenergic receptor signaling pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| Reactome | Adrenoceptors | ||||
| Adrenaline signalling through Alpha-2 adrenergic receptor | |||||
| Adrenaline,noradrenaline inhibits insulin secretion | |||||
| G alpha (i) signalling events | |||||
| G alpha (z) signalling events | |||||
| Surfactant metabolism | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| Platelet Aggregation (Plug Formation) | |||||
| Integration of energy metabolism | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002059) | ||||
| REF 2 | GYKI-12743 a new postsynaptic vascular alpha-adrenoceptor antagonist. Acta Physiol Hung. 1991;77(3-4):257-67. | ||||
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