| Drug General Information |
| Drug ID |
D0M4SY
|
| Former ID |
DNC005781
|
| Drug Name |
BMS-536924
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C25H26ClN5O3
|
| Canonical SMILES |
CC1=CC(=CC2=C1NC(=C3C(=CC=NC3=O)NCC(C4=CC(=CC=C4)Cl)O)N<br />2)N5CCOCC5
|
| InChI |
1S/C25H26ClN5O3/c1-15-11-18(31-7-9-34-10-8-31)13-20-23(15)30-24(29-20)22-19(5-6-27-25(22)33)28-14-21(32)16-3-2-4-17(26)12-16/h2-6,11-13,21,28-30,32H,7-10,14H2,1H3/b24-22-/t21-/m1/s1
|
| InChIKey |
UGQMURPIMYALPH-KKPVDXMRSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Alpha platelet-derived growth factor receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| RAC serine/threonine-protein kinase |
Target Info |
Inhibitor |
[1]
|
| Vascular endothelial growth factor receptor 2 |
Target Info |
Inhibitor |
[1]
|
| Lck tyrosine kinase |
Target Info |
Inhibitor |
[1]
|
| Hepatocyte growth factor receptor |
Target Info |
Inhibitor |
[1]
|
| Cytochrome P450 3A4 |
Target Info |
Inhibitor |
[2]
|
| G1/S-specific cyclin E1 |
Target Info |
Inhibitor |
[1]
|
| Focal adhesion kinase |
Target Info |
Inhibitor |
[1]
|
| Beta platelet-derived growth factor receptor |
Target Info |
Inhibitor |
[1]
|
| Insulin-like growth factor I receptor |
Target Info |
Inhibitor |
[3]
|
| Mitogen-activated protein kinase 1 |
Target Info |
Inhibitor |
[1]
|
| Cell division protein kinase 2 |
Target Info |
Inhibitor |
[1]
|
| mRNA of HER2 |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
MAPK signaling pathway
|
|
Ras signaling pathway
|
|
Rap1 signaling pathway
|
|
Calcium signaling pathway
|
|
Cytokine-cytokine receptor interaction
|
|
Endocytosis
|
|
PI3K-Akt signaling pathway
|
|
Focal adhesion
|
|
Gap junction
|
|
Regulation of actin cytoskeleton
|
|
HTLV-I infection
|
|
Pathways in cancer
|
|
MicroRNAs in cancer
|
|
Glioma
|
|
Prostate cancer
|
|
Melanoma
|
|
Central carbon metabolism in cancer
|
|
Choline metabolism in cancerhsa04010:MAPK signaling pathway
|
|
ErbB signaling pathway
|
|
cGMP-PKG signaling pathway
|
|
cAMP signaling pathway
|
|
Chemokine signaling pathway
|
|
HIF-1 signaling pathway
|
|
FoxO signaling pathway
|
|
Sphingolipid signaling pathway
|
|
mTOR signaling pathway
|
|
AMPK signaling pathway
|
|
Apoptosis
|
|
Adrenergic signaling in cardiomyocytes
|
|
VEGF signaling pathway
|
|
Osteoclast differentiation
|
|
Tight junction
|
|
Signaling pathways regulating pluripotency of stem cells
|
|
Platelet activation
|
|
Toll-like receptor signaling pathway
|
|
Jak-STAT signaling pathway
|
|
T cell receptor signaling pathway
|
|
B cell receptor signaling pathway
|
|
Fc epsilon RI signaling pathway
|
|
Fc gamma R-mediated phagocytosis
|
|
TNF signaling pathway
|
|
Neurotrophin signaling pathway
|
|
Cholinergic synapse
|
|
Dopaminergic synapse
|
|
Insulin signaling pathway
|
|
Progesterone-mediated oocyte maturation
|
|
Estrogen signaling pathway
|
|
Prolactin signaling pathway
|
|
Thyroid hormone signaling pathway
|
|
Adipocytokine signaling pathway
|
|
Glucagon signaling pathway
|
|
Regulation of lipolysis in adipocytes
|
|
Non-alcoholic fatty liver disease (NAFLD)
|
|
Carbohydrate digestion and absorption
|
|
Chagas disease (American trypanosomiasis)
|
|
Toxoplasmosis
|
|
Tuberculosis
|
|
Hepatitis C
|
|
Hepatitis B
|
|
Measles
|
|
Influenza A
|
|
Epstein-Barr virus infection
|
|
Proteoglycans in cancer
|
|
Colorectal cancer
|
|
Renal cell carcinoma
|
|
Pancreatic cancer
|
|
Endometrial cancer
|
|
Chronic myeloid leukemia
|
|
Acute myeloid leukemia
|
|
Small cell lung cancer
|
|
Non-small cell lung cancer
|
|
Choline metabolism in cancerhsa04014:Ras signaling pathway
|
|
Proteoglycans in cancerhsa04064:NF-kappa B signaling pathway
|
|
Natural killer cell mediated cytotoxicity
|
|
Primary immunodeficiencyhsa04014:Ras signaling pathway
|
|
Axon guidance
|
|
Adherens junction
|
|
Bacterial invasion of epithelial cells
|
|
Epithelial cell signaling in Helicobacter pylori infection
|
|
Malaria
|
|
Transcriptional misregulation in cancer
|
|
Central carbon metabolism in cancerhsa00140:Steroid hormone biosynthesis
|
|
Linoleic acid metabolism
|
|
Retinol metabolism
|
|
Metabolism of xenobiotics by cytochrome P450
|
|
Drug metabolism - cytochrome P450
|
|
Drug metabolism - other enzymes
|
|
Metabolic pathways
|
|
Bile secretion
|
|
Chemical carcinogenesishsa04110:Cell cycle
|
|
Oocyte meiosis
|
|
p53 signaling pathway
|
|
Viral carcinogenesis
|
|
Small cell lung cancerhsa04012:ErbB signaling pathway
|
|
Leukocyte transendothelial migration
|
|
Amoebiasis
|
|
Small cell lung cancerhsa04010:MAPK signaling pathway
|
|
Long-term depression
|
|
Ovarian steroidogenesis
|
|
Melanomahsa04010:MAPK signaling pathway
|
|
Vascular smooth muscle contraction
|
|
Dorso-ventral axis formation
|
|
TGF-beta signaling pathway
|
|
NOD-like receptor signaling pathway
|
|
Circadian entrainment
|
|
Long-term potentiation
|
|
Retrograde endocannabinoid signaling
|
|
Glutamatergic synapse
|
|
Serotonergic synapse
|
|
GnRH signaling pathway
|
|
Melanogenesis
|
|
Oxytocin signaling pathway
|
|
Type II diabetes mellitus
|
|
Aldosterone-regulated sodium reabsorption
|
|
Alzheimer's disease
|
|
Prion diseases
|
|
Alcoholism
|
|
Shigellosis
|
|
Salmonella infection
|
|
Pertussis
|
|
Leishmaniasis
|
|
Thyroid cancer
|
|
Bladder cancer
|
|
Choline metabolism in cancerhsa04068:FoxO signaling pathway
|
|
Cell cycle
|
|
Herpes simplex infection
|
|
NetPath Pathway
|
TGF_beta_Receptor Signaling PathwayNetPath_23:TSH Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_11:TCR Signaling Pathway
|
|
IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
|
|
TCR Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_11:TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
|
|
PANTHER Pathway
|
Angiogenesis
|
|
PDGF signaling pathwayP00005:Angiogenesis
|
|
Apoptosis signaling pathway
|
|
EGF receptor signaling pathway
|
|
Endothelin signaling pathway
|
|
FGF signaling pathway
|
|
Huntington disease
|
|
Hypoxia response via HIF activation
|
|
Inflammation mediated by chemokine and cytokine signaling pathway
|
|
Insulin/IGF pathway-protein kinase B signaling cascade
|
|
Interleukin signaling pathway
|
|
PI3 kinase pathway
|
|
T cell activation
|
|
VEGF signaling pathway
|
|
p53 pathway
|
|
Ras Pathway
|
|
p53 pathway by glucose deprivation
|
|
p53 pathway feedback loops 2
|
|
CCKR signaling map STP00005:Angiogenesis
|
|
VEGF signaling pathwayP00049:Parkinson disease
|
|
T cell activationP00013:Cell cycle
|
|
Parkinson disease
|
|
p53 pathway feedback loops 2P00005:Angiogenesis
|
|
Integrin signalling pathway
|
|
PDGF signaling pathwayP00032:Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
|
|
Insulin/IGF pathway-protein kinase B signaling cascadeP00003:Alzheimer disease-amyloid secretase pathway
|
|
B cell activation
|
|
Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
|
|
Interferon-gamma signaling pathway
|
|
PDGF signaling pathway
|
|
TGF-beta signaling pathway
|
|
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
|
|
CCKR signaling map STP00059:p53 pathway
|
|
p53 pathway feedback loops 2P00012:Cadherin signaling pathway
|
|
Pathway Interaction Database
|
ATF-2 transcription factor network
|
|
PDGFR-alpha signaling pathway
|
|
PDGF receptor signaling networksmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
|
|
Fc-epsilon receptor I signaling in mast cells
|
|
Endothelins
|
|
BCR signaling pathway
|
|
LPA receptor mediated events
|
|
Insulin Pathway
|
|
IL4-mediated signaling events
|
|
TCR signaling in naï
|
|
Plasma membrane estrogen receptor signaling
|
|
CD40/CD40L signaling
|
|
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
|
|
Signaling events mediated by PTP1B
|
|
S1P3 pathway
|
|
Coregulation of Androgen receptor activity
|
|
Reelin signaling pathway
|
|
Integrin-linked kinase signaling
|
|
TCR signaling in naï
|
|
Angiopoietin receptor Tie2-mediated signaling
|
|
FAS (CD95) signaling pathway
|
|
Thromboxane A2 receptor signaling
|
|
Regulation of Telomerase
|
|
FOXA2 and FOXA3 transcription factor networks
|
|
Glucocorticoid receptor regulatory network
|
|
mTOR signaling pathway
|
|
CXCR4-mediated signaling events
|
|
IGF1 pathway
|
|
FoxO family signaling
|
|
IL2 signaling events mediated by PI3K
|
|
Ceramide signaling pathway
|
|
p75(NTR)-mediated signaling
|
|
E-cadherin signaling in the nascent adherens junction
|
|
amb2 Integrin signaling
|
|
Integrins in angiogenesis
|
|
IFN-gamma pathway
|
|
ErbB1 downstream signaling
|
|
ErbB2/ErbB3 signaling events
|
|
IL6-mediated signaling events
|
|
E-cadherin signaling in keratinocytes
|
|
Nephrin/Neph1 signaling in the kidney podocyte
|
|
Retinoic acid receptors-mediated signaling
|
|
IL8- and CXCR2-mediated signaling events
|
|
Signaling events mediated by the Hedgehog family
|
|
Nongenotropic Androgen signaling
|
|
Hedgehog signaling events mediated by Gli proteins
|
|
Caspase Cascade in Apoptosis
|
|
CXCR3-mediated signaling events
|
|
VEGFR1 specific signals
|
|
Signaling events mediated by Stem cell factor receptor (c-Kit)
|
|
Signaling events mediated by VEGFR1 and VEGFR2
|
|
a6b1 and a6b4 Integrin signaling
|
|
Aurora A signaling
|
|
Insulin-mediated glucose transport
|
|
Class I PI3K signaling events mediated by Akt
|
|
IL8- and CXCR1-mediated signaling events
|
|
HIF-1-alpha transcription factor network
|
|
p53 pathway
|
|
Trk receptor signaling mediated by PI3K and PLC-gamma
|
|
VEGFR3 signaling in lymphatic endothelium
|
|
FGF signaling pathwayhif2pathway:HIF-2-alpha transcription factor network
|
|
Beta3 integrin cell surface interactions
|
|
Signaling events mediated by TCPTP
|
|
SHP2 signaling
|
|
S1P1 pathway
|
|
VEGF and VEGFR signaling network
|
|
Notch-mediated HES/HEY networknfkappabatypicalpathway:Atypical NF-kappaB pathway
|
|
Glypican 1 network
|
|
IL12-mediated signaling events
|
|
Regulation of p38-alpha and p38-beta
|
|
IL2-mediated signaling events
|
|
Class I PI3K signaling events
|
|
EPHA forward signaling
|
|
PDGFR-beta signaling pathway
|
|
IL2 signaling events mediated by STAT5
|
|
Ephrin B reverse signaling
|
|
Alpha-synuclein signalingmet_pathway:Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
|
|
Arf6 signaling events
|
|
Posttranslational regulation of adherens junction stability and dissassembly
|
|
Direct p53 effectors
|
|
Syndecan-1-mediated signaling events
|
|
Stabilization and expansion of the E-cadherin adherens junction
|
|
FGF signaling pathway
|
|
Regulation of retinoblastoma proteinprlsignalingeventspathway:Signaling events mediated by PRL
|
|
E2F transcription factor network
|
|
FOXM1 transcription factor network
|
|
BARD1 signaling events
|
|
PLK3 signaling events
|
|
Regulation of retinoblastoma proteinlysophospholipid_pathway:LPA receptor mediated events
|
|
CXCR4-mediated signaling eventsptp1bpathway:Signaling events mediated by PTP1B
|
|
Nectin adhesion pathway
|
|
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
|
|
Validated targets of C-MYC transcriptional repression
|
|
PDGF receptor signaling networker_nongenomic_pathway:Plasma membrane estrogen receptor signaling
|
|
Stabilization and expansion of the E-cadherin adherens junctionfcer1pathway:Fc-epsilon receptor I signaling in mast cells
|
|
Signaling events mediated by PRL
|
|
ErbB4 signaling events
|
|
GMCSF-mediated signaling events
|
|
EPHB forward signaling
|
|
Osteopontin-mediated events
|
|
S1P4 pathway
|
|
Presenilin action in Notch and Wnt signaling
|
|
TRAIL signaling pathway
|
|
CDC42 signaling events
|
|
Signaling events regulated by Ret tyrosine kinase
|
|
Netrin-mediated signaling events
|
|
Arf6 downstream pathway
|
|
Class IB PI3K non-lipid kinase events
|
|
EGF receptor (ErbB1) signaling pathway
|
|
Ras signaling in the CD4+ TCR pathway
|
|
BMP receptor signaling
|
|
ALK1 signaling events
|
|
Neurotrophic factor-mediated Trk receptor signaling
|
|
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
|
|
Syndecan-2-mediated signaling events
|
|
Cellular roles of Anthrax toxin
|
|
S1P2 pathway
|
|
Trk receptor signaling mediated by the MAPK pathway
|
|
Downstream signaling in naï
|
|
Alpha-synuclein signaling
|
|
Signaling events mediated by focal adhesion kinasesmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
|
|
p73 transcription factor network
|
|
ATR signaling pathway
|
|
Regulation of retinoblastoma proteinerbb4_pathway:ErbB4 signaling events
|
|
ErbB receptor signaling network
|
|
PathWhiz Pathway
|
Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
|
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
|
|
Fc Epsilon Receptor I Signaling in Mast Cells
|
|
Insulin Signalling
|
|
Leucine Stimulation on Insulin SignalingPW000015:Caffeine Metabolism
|
|
Retinol MetabolismPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
|
|
Insulin SignallingPW000168:Phosphatidylinositol Phosphate Metabolism
|
|
Reactome
|
PIP3 activates AKT signaling
|
|
Constitutive Signaling by Aberrant PI3K in Cancer
|
|
RAF/MAP kinase cascadeR-HSA-111447:Activation of BAD and translocation to mitochondria
|
|
GPVI-mediated activation cascade
|
|
Translocation of GLUT4 to the plasma membrane
|
|
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
|
|
AKT phosphorylates targets in the cytosol
|
|
AKT phosphorylates targets in the nucleus
|
|
Negative regulation of the PI3K/AKT network
|
|
eNOS activation
|
|
AKT-mediated inactivation of FOXO1A
|
|
Integrin alphaIIb beta3 signaling
|
|
Deactivation of the beta-catenin transactivating complex
|
|
CD28 dependent PI3K/Akt signaling
|
|
CTLA4 inhibitory signaling
|
|
G beta:gamma signalling through PI3Kgamma
|
|
KSRP (KHSRP) binds and destabilizes mRNA
|
|
VEGFR2 mediated vascular permeability
|
|
TP53 Regulates Metabolic Genes
|
|
Constitutive Signaling by AKT1 E17K in CancerR-HSA-194306:Neurophilin interactions with VEGF and VEGFR
|
|
VEGF binds to VEGFR leading to receptor dimerization
|
|
Integrin cell surface interactions
|
|
EPHA-mediated growth cone collapse
|
|
VEGFA-VEGFR2 Pathway
|
|
VEGFR2 mediated cell proliferationR-HSA-114604:GPVI-mediated activation cascade
|
|
Regulation of KIT signaling
|
|
Phosphorylation of CD3 and TCR zeta chains
|
|
Translocation of ZAP-70 to Immunological synapse
|
|
Generation of second messenger molecules
|
|
PECAM1 interactions
|
|
DAP12 signaling
|
|
CD28 co-stimulation
|
|
CD28 dependent Vav1 pathway
|
|
PD-1 signaling
|
|
Interleukin-2 signalingR-HSA-416550:Sema4D mediated inhibition of cell attachment and migrationR-HSA-211981:Xenobiotics
|
|
Aflatoxin activation and detoxificationR-HSA-113510:E2F mediated regulation of DNA replication
|
|
G0 and Early G1
|
|
SCF(Skp2)-mediated degradation of p27/p21
|
|
DNA Damage/Telomere Stress Induced Senescence
|
|
Cyclin E associated events during G1/S transition
|
|
G1/S-Specific Transcription
|
|
p53-Dependent G1 DNA Damage ResponseR-HSA-111465:Apoptotic cleavage of cellular proteins
|
|
Regulation of actin dynamics for phagocytic cup formation
|
|
GRB2:SOS provides linkage to MAPK signaling for Integrins
|
|
p130Cas linkage to MAPK signaling for integrins
|
|
NCAM signaling for neurite out-growth
|
|
Signal regulatory protein (SIRP) family interactions
|
|
EPHB-mediated forward signaling
|
|
DCC mediated attractive signaling
|
|
Netrin mediated repulsion signals
|
|
RHO GTPases Activate WASPs and WAVEs
|
|
RAF/MAP kinase cascadeR-HSA-1257604:PIP3 activates AKT signaling
|
|
RAF/MAP kinase cascadeR-HSA-2428928:IRS-related events triggered by IGF1R
|
|
SHC-related events triggered by IGF1RR-HSA-112409:RAF-independent MAPK1/3 activation
|
|
MAPK1 (ERK2) activation
|
|
Golgi Cisternae Pericentriolar Stack Reorganization
|
|
ERK/MAPK targets
|
|
Oxidative Stress Induced Senescence
|
|
Senescence-Associated Secretory Phenotype (SASP)
|
|
Oncogene Induced Senescence
|
|
FCERI mediated MAPK activation
|
|
Regulation of HSF1-mediated heat shock response
|
|
Recycling pathway of L1
|
|
CREB phosphorylation through the activation of Ras
|
|
Activation of the AP-1 family of transcription factors
|
|
Thrombin signalling through proteinase activated receptors (PARs)
|
|
Negative regulation of FGFR1 signaling
|
|
Negative regulation of FGFR2 signaling
|
|
Negative regulation of FGFR3 signaling
|
|
Negative regulation of FGFR4 signaling
|
|
RAF/MAP kinase cascade
|
|
MAP2K and MAPK activation
|
|
Negative feedback regulation of MAPK pathway
|
|
Negative regulation of MAPK pathway
|
|
Signal attenuation
|
|
Advanced glycosylation endproduct receptor signaling
|
|
Gastrin-CREB signalling pathway via PKC and MAPK
|
|
Growth hormone receptor signalingR-HSA-1538133:G0 and Early G1
|
|
Activation of ATR in response to replication stress
|
|
Regulation of APC/C activators between G1/S and early anaphase
|
|
Processing of DNA double-strand break ends
|
|
G2 Phase
|
|
Orc1 removal from chromatin
|
|
Cyclin A/B1 associated events during G2/M transition
|
|
p53-Dependent G1 DNA Damage Response
|
|
Cyclin A:Cdk2-associated events at S phase entry
|
|
Meiotic recombination
|
|
Factors involved in megakaryocyte development and platelet productionR-HSA-1250196:SHC1 events in ERBB2 signaling
|
|
PLCG1 events in ERBB2 signaling
|
|
GRB2 events in ERBB2 signaling
|
|
PI3K events in ERBB2 signaling
|
|
Sema4D induced cell migration and growth-cone collapse
|
|
WikiPathways
|
Regulation of Actin Cytoskeleton
|
|
Osteoblast Signaling
|
|
Focal Adhesion
|
|
Hair Follicle Development: Organogenesis (Part 2 of 3)
|
|
PIP3 activates AKT signaling
|
|
Cardiac Progenitor Differentiation
|
|
Integrated Pancreatic Cancer Pathway
|
|
Allograft Rejection
|
|
Signaling Pathways in Glioblastoma
|
|
Signaling by PDGF
|
|
AngiogenesisWP75:Toll-like receptor signaling pathway
|
|
DNA Damage Response (only ATM dependent)
|
|
TCR Signaling Pathway
|
|
Notch Signaling Pathway
|
|
EPO Receptor Signaling
|
|
IL-2 Signaling Pathway
|
|
Insulin Signaling
|
|
Endochondral Ossification
|
|
EGF/EGFR Signaling Pathway
|
|
IL-4 Signaling Pathway
|
|
TGF beta Signaling Pathway
|
|
IL-6 signaling pathway
|
|
Wnt Signaling Pathway Netpath
|
|
Copper homeostasis
|
|
Extracellular vesicle-mediated signaling in recipient cells
|
|
Apoptosis-related network due to altered Notch3 in ovarian cancer
|
|
IL-3 Signaling Pathway
|
|
Cardiac Hypertrophic Response
|
|
Translocation of GLUT4 to the Plasma Membrane
|
|
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
|
|
Signal Transduction of S1P Receptor
|
|
T-Cell Receptor and Co-stimulatory Signaling
|
|
Primary Focal Segmental Glomerulosclerosis FSGS
|
|
Apoptosis
|
|
Alpha 6 Beta 4 signaling pathway
|
|
BDNF signaling pathway
|
|
Oncostatin M Signaling Pathway
|
|
Corticotropin-releasing hormone
|
|
Interleukin-11 Signaling Pathway
|
|
AGE/RAGE pathway
|
|
TNF alpha Signaling Pathway
|
|
B Cell Receptor Signaling Pathway
|
|
Prostate Cancer
|
|
TSLP Signaling Pathway
|
|
IL17 signaling pathway
|
|
IL-7 Signaling Pathway
|
|
Regulation of Microtubule Cytoskeleton
|
|
TWEAK Signaling Pathway
|
|
FSH signaling pathway
|
|
Leptin signaling pathway
|
|
TSH signaling pathway
|
|
RANKL/RANK Signaling Pathway
|
|
Integrated Breast Cancer Pathway
|
|
SREBP signalling
|
|
Integrated Cancer pathway
|
|
IL-1 signaling pathway
|
|
Metabolism of nitric oxide
|
|
Integrin-mediated Cell Adhesion
|
|
TFs Regulate miRNAs related to cardiac hypertrophy
|
|
MicroRNAs in cardiomyocyte hypertrophy
|
|
Angiogenesis
|
|
TOR Signaling
|
|
Regulation of toll-like receptor signaling pathway
|
|
AMPK Signaling
|
|
Androgen receptor signaling pathway
|
|
IL-5 Signaling PathwayWP306:Focal Adhesion
|
|
Nifedipine Activity
|
|
Signaling by VEGF
|
|
AngiogenesisWP61:Notch Signaling Pathway
|
|
Interferon type I signaling pathways
|
|
Inflammatory Response Pathway
|
|
Signaling by SCF-KIT
|
|
DAP12 interactions
|
|
Host Interactions of HIV factors
|
|
TCR signaling
|
|
Costimulation by the CD28 familyWP366:TGF beta Signaling Pathway
|
|
Signaling of Hepatocyte Growth Factor Receptor
|
|
miR-targeted genes in squamous cell - TarBase
|
|
miR-targeted genes in muscle cell - TarBase
|
|
miR-targeted genes in lymphocytes - TarBase
|
|
miR-targeted genes in epithelium - TarBase
|
|
Semaphorin interactionsWP702:Metapathway biotransformation
|
|
Aflatoxin B1 metabolism
|
|
Estrogen metabolism
|
|
Benzo(a)pyrene metabolism
|
|
Tamoxifen metabolism
|
|
Tryptophan metabolism
|
|
Oxidation by Cytochrome P450
|
|
Nuclear Receptors in Lipid Metabolism and Toxicity
|
|
Nuclear Receptors Meta-Pathway
|
|
Farnesoid X Receptor Pathway
|
|
Vitamin D Receptor Pathway
|
|
Felbamate Metabolism
|
|
Lidocaine metabolism
|
|
Colchicine Metabolic Pathway
|
|
Irinotecan Pathway
|
|
Drug Induction of Bile Acid Pathway
|
|
Fatty Acid Omega Oxidation
|
|
Codeine and Morphine MetabolismWP707:DNA Damage Response
|
|
ID signaling pathway
|
|
G1 to S cell cycle control
|
|
Retinoblastoma (RB) in Cancer
|
|
Parkinsons Disease Pathway
|
|
Parkin-Ubiquitin Proteasomal System pathway
|
|
Mitotic G1-G1/S phases
|
|
Cell Cycle
|
|
miRNAs involved in DNA damage response
|
|
miRNA Regulation of DNA Damage Response
|
|
Androgen receptor signaling pathwayWP51:Regulation of Actin Cytoskeleton
|
|
Nanoparticle-mediated activation of receptor signaling
|
|
JAK/STAT
|
|
Netrin-1 signaling
|
|
NCAM signaling for neurite out-growth
|
|
Integrin alphaIIb beta3 signaling
|
|
Apoptotic execution phase
|
|
MAPK Signaling Pathway
|
|
PDGF Pathway
|
|
Signaling by PDGFWP615:Senescence and Autophagy in Cancer
|
|
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
|
|
MicroRNAs in cardiomyocyte hypertrophyWP75:Toll-like receptor signaling pathway
|
|
Serotonin Receptor 4/6/7 and NR3C Signaling
|
|
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
|
|
Serotonin HTR1 Group and FOS Pathway
|
|
Vitamin A and Carotenoid Metabolism
|
|
ErbB Signaling Pathway
|
|
Hypothetical Network for Drug Addiction
|
|
Senescence and Autophagy in Cancer
|
|
MAPK Cascade
|
|
Kit receptor signaling pathway
|
|
TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
|
|
Bladder Cancer
|
|
MAP kinase activation in TLR cascade
|
|
Fc epsilon receptor (FCERI) signaling
|
|
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
|
|
RAF/MAP kinase cascade
|
|
Structural Pathway of Interleukin 1 (IL-1)
|
|
Genes and (Common) Pathways Underlying Drug Addiction
|
|
EBV LMP1 signaling
|
|
Aryl Hydrocarbon Receptor
|
|
Spinal Cord Injury
|
|
IL-9 Signaling Pathway
|
|
Endothelin Pathways
|
|
Alzheimers Disease
|
|
Opioid Signalling
|
|
Thrombin signalling through proteinase activated receptors (PARs)
|
|
Signaling by FGFR
|
|
L1CAM interactions
|
|
Advanced glycosylation endproduct receptor signaling
|
|
Heart Development
|
|
Type II diabetes mellitus
|
|
Physiological and Pathological Hypertrophy of the Heart
|
|
Osteopontin Signaling
|
|
IL-5 Signaling PathwayWP707:DNA Damage Response
|
|
DNA Replication
|
|
M/G1 Transition
|
|
S Phase
|
|
Meiotic Recombination
|
|
ATM Signaling Pathway
|
|
Synthesis of DNA
|
|
Regulation of DNA replication
|
|
Mitotic G2-G2/M phases
|
|
Factors involved in megakaryocyte development and platelet production
|
|
APC/C-mediated degradation of cell cycle proteins
|
|
Cell Cycle Checkpoints
|
|
miRNA Regulation of DNA Damage ResponseWP710:DNA Damage Response (only ATM dependent)
|
|
Signaling by ERBB2
|
|
Semaphorin interactions
|
| References |
| REF 1 | J Med Chem. 2005 Sep 8;48(18):5639-43.Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitumor activity. |
|---|
| REF 2 | J Med Chem. 2008 Oct 9;51(19):5897-900. Epub 2008 Sep 3.Discovery and evaluation of 4-(2-(4-chloro-1H-pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one (BMS-695735), an orally efficacious inhibitor of insulin-like growth factor-1 receptor kinase with broad spectrum in vivo antitumor activity. |
|---|
| REF 3 | Bioorg Med Chem Lett. 2010 Mar 1;20(5):1744-8. Epub 2010 Jan 21.SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors. |
|---|
