Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0LJ1B
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| Former ID |
DCL000955
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| Drug Name |
Reparixin
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| Synonyms |
Repertaxin; Reparixin [INN]; Reparixin (INN/USAN); (R)-2-(4-isobutylphenyl)propionylmethanesulfonamide; 2-(4-isobutylphenyl)propionylmethanesulfonamide
|
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| Drug Type |
Small molecular drug
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| Indication | Ischemia-reperfusion injury; Lung transplantation; Graft rejection in heart transplantation [ICD9: 996, 996.84; ICD10:T86, T86.81] | Phase 2 | [1], [2] | ||
| Company |
Dompe s.p.a.
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| Structure |
|
Download2D MOL |
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| Formula |
C14H21NO3S
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| InChI |
InChI=1S/C14H21NO3S/c1-10(2)9-12-5-7-13(8-6-12)11(3)14(16)15-19(4,17)18/h5-8,10-11H,9H2,1-4H3,(H,15,16)/t11-/m1/s1
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| InChIKey |
KQDRVXQXKZXMHP-LLVKDONJSA-N
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| CAS Number |
CAS 266359-93-7
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | High affinity interleukin-8 receptor B | Target Info | Modulator | ||
| High affinity interleukin-8 receptor A | Target Info | Modulator | |||
| KEGG Pathway | Cytokine-cytokine receptor interaction | ||||
| Chemokine signaling pathway | |||||
| Endocytosis | |||||
| Epithelial cell signaling in Helicobacter pylori infectionhsa04060:Cytokine-cytokine receptor interaction | |||||
| Epithelial cell signaling in Helicobacter pylori infection | |||||
| NetPath Pathway | TNFalpha Signaling PathwayNetPath_14:IL2 Signaling Pathway | ||||
| PANTHER Pathway | Inflammation mediated by chemokine and cytokine signaling pathway | ||||
| Interleukin signaling pathwayP00031:Inflammation mediated by chemokine and cytokine signaling pathway | |||||
| Interleukin signaling pathway | |||||
| Pathway Interaction Database | IL8- and CXCR2-mediated signaling eventsil8cxcr1_pathway:IL8- and CXCR1-mediated signaling events | ||||
| Reactome | Chemokine receptors bind chemokines | ||||
| G alpha (i) signalling eventsR-HSA-380108:Chemokine receptors bind chemokines | |||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCRs, Class A Rhodopsin-like | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like | |||||
| Differentiation Pathway | |||||
| GPCRs, Other | |||||
| References | |||||
| REF 1 | New developments in immunosuppressive therapy for heart transplantation. Expert Opin Emerg Drugs. 2009 Mar;14(1):1-21. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8498). | ||||
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