Drug Information

Drug General Information
Drug ID
D0L8MO
Former ID
DIB003461
Drug Name
ME-3407
Synonyms
EF-4040; 2-(Butoxycarbonylmethylsulfinyl)thiazolo[5,4-b]pyridine; 2-(Thiazolo[5,4-b]pyridin-2-ylsulfinyl)acetic acid butyl ester
Drug Type
Small molecular drug
Indication Duodenal ulcers [ICD10:K25-K27] Phase 2 [534394]
Structure
Download
2D MOL

3D MOL
Formula
C12H14N2O3S2
Canonical SMILES
CCCCOC(=O)CS(=O)C1=NC2=C(S1)N=CC=C2
InChI
1S/C12H14N2O3S2/c1-2-3-7-17-10(15)8-19(16)12-14-9-5-4-6-13-11(9)18-12/h4-6H,2-3,7-8H2,1H3
InChIKey
BUXNKFNNJJTLOS-UHFFFAOYSA-N
CAS Number
CAS 133903-90-9
PubChem Compound ID
6918179
PubChem Substance ID
12014576, 14800392, 17194722, 43529569, 49862823, 57371827, 74690194, 114787557, 127571706, 224940200, 232201673
Target and Pathway
Target(s) Myosin light chain kinase, smooth muscle and non-muscle isozymes Target Info Inhibitor [534394]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Vascular smooth muscle contraction
Focal adhesion
Platelet activation
Regulation of actin cytoskeleton
Oxytocin signaling pathway
Gastric acid secretion
PANTHER Pathway Cytoskeletal regulation by Rho GTPase
Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database Aurora B signaling
PathWhiz Pathway Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
Muscle/Heart Contraction
Reactome Smooth Muscle Contraction
WikiPathways Regulation of Actin Cytoskeleton
Focal Adhesion
Endothelin Pathways
Muscle contraction
MicroRNAs in cardiomyocyte hypertrophy
References
Ref 534394ME-3407, a new antiulcer agent, inhibits acid secretion by interfering with redistribution of H(+)-K(+)-ATPase. Am J Physiol. 1997 May;272(5 Pt 1):G1122-34.
Ref 534394ME-3407, a new antiulcer agent, inhibits acid secretion by interfering with redistribution of H(+)-K(+)-ATPase. Am J Physiol. 1997 May;272(5 Pt 1):G1122-34.

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