Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0L7IZ
|
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| Former ID |
DIB020118
|
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| Drug Name |
JP1302
|
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| Synonyms |
JP-1302; MMV006172
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C24H24N4
|
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| InChI |
InChI=1S/C24H24N4/c1-27-14-16-28(17-15-27)19-12-10-18(11-13-19)25-24-20-6-2-4-8-22(20)26-23-9-5-3-7-21(23)24/h2-13H,14-17H2,1H3,(H,25,26)
|
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| InChIKey |
QZKGUNQLVFEEBA-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
3300414, 7366243, 7856304, 8675807, 11133927, 15142450, 39365431, 49864116, 50112963, 77274000, 85858371, 88781810, 103327047, 104078011, 104223782, 106030342, 109806821, 118001726, 118058131, 124893357, 129097138, 131332031, 134224241, 134344113, 135142762, 137239553, 144043926, 162726584, 170361598, 178100759, 179071657, 223746196, 227852147, 249909195, 252565603
|
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| Target and Pathway | |||||
| Target(s) | Alpha-2C adrenergic receptor | Target Info | Antagonist | [2] | |
| KEGG Pathway | cGMP-PKG signaling pathway | ||||
| Neuroactive ligand-receptor interaction | |||||
| PANTHER Pathway | Alpha adrenergic receptor signaling pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| Reactome | Adrenoceptors | ||||
| Adrenaline signalling through Alpha-2 adrenergic receptor | |||||
| Adrenaline,noradrenaline inhibits insulin secretion | |||||
| G alpha (i) signalling events | |||||
| G alpha (z) signalling events | |||||
| Surfactant metabolism | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| Platelet Aggregation (Plug Formation) | |||||
| Integration of energy metabolism | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3930). | ||||
| REF 2 | Pharmacological characterization and CNS effects of a novel highly selective alpha2C-adrenoceptor antagonist JP-1302. Br J Pharmacol. 2007 Feb;150(4):391-402. Epub 2007 Jan 15. | ||||
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