Drug Information

Drug General Information
Drug ID
D0L5CZ
Former ID
DAP000349
Drug Name
Rocuronium
Synonyms
Esmeron (TN); Zemuron (TN); (2beta,3alpha,5alpha,16beta,17beta)-17-acetoxy-16-(1-allylpyrrolidinium-1-yl)-3-hydroxy-2-(morpholin-4-yl)androstane; [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3-hydroxy-10,13-dimethyl-2-morpholin-4-yl-16-(1-prop-2-enylpyrrolidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
Drug Type
Small molecular drug
Indication Muscle relaxant [ICD10:N39.3, N39.4, R32] Approved [551871]
Therapeutic Class
Neuromuscular Nondepolarizing Agents
Company
Gland Pharma Ltd
Structure
Download
2D MOL

3D MOL
Formula
C32H53N2O4+
InChI
InChI=1S/C32H53N2O4/c1-5-14-34(15-6-7-16-34)28-20-26-24-9-8-23-19-29(36)27(33-12-17-37-18-13-33)21-32(23,4)25(24)10-11-31(26,3)30(28)38-22(2)35/h5,23-30,36H,1,6-21H2,2-4H3/q+1/t23-,24+,25-,26-,27-,28-,29-,30-,31-,32-/m0/s1
InChIKey
YXRDKMPIGHSVRX-OOJCLDBCSA-N
CAS Number
CAS 119302-91-9
PubChem Compound ID
441290
PubChem Substance ID
9759, 7980535, 10298784, 36885162, 46506855, 50112687, 57403615, 76758492, 87322634, 92309079, 92729760, 93166518, 104625114, 123090170, 134337660, 136177198, 137004290, 152258743, 160647588, 160964072, 162177643, 162201757, 163306169, 163414334, 175266560, 175443879, 176484263, 176484981, 178100829, 179149670, 184811987, 223383273, 224380718, 226416911, 241035612, 251916699, 251917938, 252356492
SuperDrug ATC ID
M03AC09
SuperDrug CAS ID
cas=119302919
Target and Pathway
Target(s) Neuronal acetylcholinereceptor subunit alpha-2 Target Info Antagonist [536781], [537286]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Nicotinic acetylcholine receptor signaling pathway
Reactome Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptors
WikiPathways Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 536781Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors. Anesth Analg. 2008 Aug;107(2):525-33.
Ref 537286Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52.

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