Drug Information

Drug General Information
Drug ID
D0L4ZK
Former ID
DIB012925
Drug Name
RG-7351
Synonyms
TAAR1 part agonist (depression), Roche; Trace amine-associated receptor 1 part agonist (depression), Roche
Indication Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] Phase 1 [549026]
Company
Roche Holding AG
Target and Pathway
Target(s) Trace amine-associated receptor-1 Target Info Agonist [526471], [526676], [532175], [532852], [551610], [551871]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome G alpha (s) signalling events
References
Ref 549026Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031597)
Ref 526471Methamphetamine increases the hippocampal alpha(2A)-adrenergic receptor and Galpha(o) in mice. Neurosci Lett. 2002 Dec 16;334(3):145-8.
Ref 526676Alpha-1B adrenergic receptor knockout mice are protected against methamphetamine toxicity. J Neurochem. 2003 Jul;86(2):413-21.
Ref 532175Involvement of the alpha(1D)-adrenergic receptor in methamphetamine-induced hyperthermia and neurotoxicity in rats. Neurotox Res. 2013 Aug;24(2):130-8.
Ref 532852Methamphetamine and HIV-1-induced neurotoxicity: role of trace amine associated receptor 1 cAMP signaling in astrocytes. Neuropharmacology. 2014 Oct;85:499-507.
Ref 551610Clinical pipeline report, company report or official report of Roche.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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