TTD | Drug: D0L4IV

Drug General Information
Drug ID	D0L4IV
Former ID	DIB018794
Drug Name	AL12180
Synonyms	5,6-dihydro-4,5-didehydro-11-deoxy-11-oxa-16-(3-chlorophenoxy)-omega-tetranor-PGF2alpha; AL-12180
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540334]
Structure		Download 2D MOL
Formula	C21H27ClO6
InChI	InChI=1S/C21H27ClO6/c22-15-6-5-7-17(12-15)27-13-16(23)10-11-20-18(19(24)14-28-20)8-3-1-2-4-9-21(25)26/h1-2,5-7,10-12,16,18-20,23-24H,3-4,8-9,13-14H2,(H,25,26)/b2-1-,11-10+/t16-,18+,19+,20-/m1/s1
InChIKey	GLYAVTUPQOQHAD-MOBTWWNESA-N
PubChem Compound ID	59107184
PubChem Substance ID	140326539, 172650382, 178100403, 198973933, 237031680
Target and Pathway
Target(s)	Prostaglandin F2-alpha receptor	Target Info	Agonist	[528506]
KEGG Pathway	Calcium signaling pathway
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	Prostanoid ligand receptors
Reactome	G alpha (q) signalling events
WikiPathways	Prostaglandin Synthesis and Regulation
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Small Ligand GPCRs
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 540334	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3386).
Ref 528506	Preclinical pharmacology of AL-12182, a new ocular hypotensive 11-oxa prostaglandin analog. J Ocul Pharmacol Ther. 2006 Oct;22(5):291-309.

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Drug Information