Drug Information

Drug General Information
Drug ID
D0L3KR
Former ID
DNC013339
Drug Name
2,2',4,4'-tetrahydroxy-6'-methoxychalcone
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528649]
Structure
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2D MOL

3D MOL
Formula
C16H14O6
Canonical SMILES
COC1=CC(=CC(=C1C(=O)C=CC2=C(C=C(C=C2)O)O)O)O
InChI
1S/C16H14O6/c1-22-15-8-11(18)7-14(21)16(15)12(19)5-3-9-2-4-10(17)6-13(9)20/h2-8,17-18,20-21H,1H3/b5-3+
InChIKey
NNOIQNQJIKZQCN-HWKANZROSA-N
PubChem Compound ID
44428616
Target and Pathway
Target(s) Tyrosine oxidase Target Info Inhibitor [528649]
BioCyc Pathway (S)-reticuline biosynthesis
Eumelanin biosynthesis
L-dopachrome biosynthesis
KEGG Pathway Tyrosine metabolism
Riboflavin metabolism
Metabolic pathways
Melanogenesis
PathWhiz Pathway Riboflavin Metabolism
Tyrosine Metabolism
WikiPathways Dopamine metabolism
References
Ref 528649Bioorg Med Chem. 2007 Mar 15;15(6):2396-402. Epub 2007 Jan 17.Synthesis and evaluation of 2',4',6'-trihydroxychalcones as a new class of tyrosinase inhibitors.
Ref 528649Bioorg Med Chem. 2007 Mar 15;15(6):2396-402. Epub 2007 Jan 17.Synthesis and evaluation of 2',4',6'-trihydroxychalcones as a new class of tyrosinase inhibitors.

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