Drug Information

Drug General Information
Drug ID
D0L1IH
Former ID
DNC000126
Drug Name
A-79175
Drug Type
Small molecular drug
Indication Asthma [ICD10:J45] Terminated [545797]
Structure
Download
2D MOL

3D MOL
Formula
C15H13FN2O4
Canonical SMILES
CC(C#CC1=CC=C(O1)OC2=CC=C(C=C2)F)N(C(=O)N)O
InChI
1S/C15H13FN2O4/c1-10(18(20)15(17)19)2-5-12-8-9-14(21-12)22-13-6-3-11(16)4-7-13/h3-4,6-10,20H,1H3,(H2,17,19)
InChIKey
OLZHFFKRBCZHHT-UHFFFAOYSA-N
CAS Number
CAS 141579-67-1
PubChem Compound ID
71460
PubChem Substance ID
7751787, 8194636, 14751875, 43127780, 47470327, 50061179, 76931594, 99222698, 103096745, 103248678, 103938795, 104350519, 104828551, 117569731, 125744888, 126448729, 128828228, 134339645, 134349079, 135029121, 137270860, 141541165, 162309056, 162791013, 227982799
Target and Pathway
Target(s) Arachidonate 5-lipoxygenase Target Info Inhibitor [537871], [538075]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Resolvin D biosynthesis
Leukotriene biosynthesis
Lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
Aspirin triggered resolvin E biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosis
NetPath Pathway IL4 Signaling Pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Vitamin D Receptor Pathway
Arachidonic acid metabolism
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 545797Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004773)
Ref 537871Stereoselective metabolism of the 5-lipoxygenase inhibitor A-78773. Ann N Y Acad Sci. 1994 Nov 15;744:262-73.
Ref 538075The role of platelet-activating factor (PAF) and the efficacy of ABT-491, a highly potent and selective PAF antagonist, in experimental allergic rhinitis. J Pharmacol Exp Ther. 1998 Jan;284(1):83-8.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.