Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0L0MO
|
||||
| Former ID |
DIB004340
|
||||
| Drug Name |
Satigrel
|
||||
| Synonyms |
E-5510
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Thromboembolism [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] | Discontinued in Preregistration | [1] | ||
| Company |
Eisai Co Ltd
|
||||
| Structure |
|
Download2D MOL |
|||
| Formula |
C20H19NO4
|
||||
| Canonical SMILES |
C(=C(C#N)CCC(=O)O)(c1ccc(cc1)OC)c1ccc(cc1)OC
|
||||
| CAS Number |
CAS 111753-73-2
|
||||
| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Thromboxane-A synthase | Target Info | Modulator | [2] | |
| BioCyc Pathway | C20 prostanoid biosynthesis | ||||
| KEGG Pathway | Arachidonic acid metabolism | ||||
| Metabolic pathways | |||||
| Platelet activation | |||||
| PathWhiz Pathway | Arachidonic Acid Metabolism | ||||
| WikiPathways | Prostaglandin Synthesis and Regulation | ||||
| Arachidonic acid metabolism | |||||
| Phase 1 - Functionalization of compounds | |||||
| Eicosanoid Synthesis | |||||
| References | |||||
| REF 1 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000441) | ||||
| REF 2 | Mechanisms of satigrel (E5510), a new anti-platelet drug, in inhibiting human platelet aggregation. Selectivity and potency against prostaglandin H synthases isozyme activities and phosphodiesterase isoform activities. Biol Pharm Bull. 1996 Jun;19(6):828-33. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.